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中文名称英文名称CAS 编号规格目录价所属品牌订货号
秋水仙素Colchicine64-86-8250MG¥330.00SIGMAC9754
秋水仙素Colchicine64-86-81G¥964.00SIGMAC9754
秋水仙素Colchicine64-86-85G¥3,700.00SIGMAC9754
秋水仙素Colchicine64-86-8100G¥49,200.00SIGMAC9754
品牌SIGMA
产品名称 秋水仙素 : Colchicine ——【产品编号:SIGMA-C9754】
CAS编号64-86-8
别名秋水仙碱,Colchicum
级别科学级
纯度&分析≥95% (HPLC), powder
Tips一种常用的研究级抗生素类制品,适用于科学研究、辅料、规模化生产等。
分子式 C22H25NO6
分子量399.44
储存条件常温避光保存。
性质
Appearance (Color) White to Yellow
Appearance (Form) Powder
Solubility (Color) Yellow to Yellow-Green
Solubility (Turbidity) Clear to Slightly Hazy
  at 50 mg/ml in ethanol
Carbon 62.8 - 67.5 %
Nitrogen 3.2 - 3.8 %
Solvent Content (by GC) ≤10 %
  Ethyl Acetate
Proton NMR spectra Conforms to Structure
Purity (HPLC) ≥95 %
Performance Pass
原产地美国
描述

Biochem/physiol Actions

Antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

供货状态True
参考文献

Luduena, R.F., et al., Tubulin structure and biochemistry. Curr. Opin. Cell Biol. 4, 53-57, (1992)

Jordan, A., et al., Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle. Med. Res. Rev. 18, 259-296, (1998)

Andreu, J.M., et al., Role of the colchicine ring A and its methoxy groups in the binding to tubulin and microtubule inhibition. Biochemistry 37, 8356-8368, (1998)

Banerjee, A., Differential effects of colchicine and its B-ring modified analog MTPT on the assembly-independent GTPase activity of purified β-tubulin isoforms from bovine brain. Biochem. Biophys. Res. Commun. 231, 698, (1997)

Suzuki, Y, Cell death, phagocytosis, and neurogenesis in mouse olfactory epithelium and vomeronasal organ after colchicine treatment. Ann. N.Y. Acad. Sci. 30, 252-254, (1998)

DeVincenzo, R., et al., Antiproliferative activity of colchicine analogues on MDR-positive and MDR-negative human cancer cell lines. Anticancer Drug Des. 13, 19-33, (1998)

Ceccatelli, S., et al., Apoptosis in rat hippocampal dentate gyrus after intraventricular colchicine. Neuroreport 8, 3779-3783, (1997)

Want, T.H., et al., Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways. J. Biol. Chem. 273, 4928-4936, (1998)

Gáspár, I., and Szabad, J., In Vivo Analysis Of MT-based Vesicle Transport By Confocal Reflection Microscopy. Cell Motil. Cytoskeleton 66, 68-79, (2009)

Karapidaki, I., et al., Genotoxic, Cytostatic, Antineoplastic And Apoptotic Effects Of Newly Synthesized Antitumour Steroidal Esters. Mol. Cell. 675, 51-9, (2009)

Ibáñez-Sandoval, O., et al., Electrophysiological And Morphological Characteristics And Synaptic Connectivity Of Tyrosine Hydroxylase-expressing Neurons In Adult Mouse Striatum. J. Neurosci. 30, 6999-7016, (2010)

Yi, M., et al., Derivation And Characterization Of Haploid Embryonic Stem Cell Cultures In Medaka Fish. Nat. Protoc. 5, 1418-30, (2010)

Zan, U., et al., In Vitro Genotoxicity Of Rocuronium Bromide In Human Peripheral Lymphocytes. Cytotechnology 63, 239-45, (2011)

Merck 14,2471

Beil. 14,IV,946

Aldrich MSDS 1, 482:D / Corp MSDS 1 (1), 903:B / FT-IR 1 (2), 361:C / FT-IR 2 (2), 2980:D / FT-NMR 1 (2), 1374:C / IR-Spectra (3), 1072:F / IR-Spectra (2), 938:B / NMR-Reference 2 (2), 340:A / RegBook 1 (2), 2007:C / Sigma FT-IR 1 (2), 403:C / Structure Index 1, 320:D:5

类型抗生素
安全信息
符号 GHS06GHS08
信号词 Danger
危险声明 H300-H340
警示性声明 P201-P264-P301 + P310-P308 + P313
个人防护装备 Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
危害码 T+
风险声明 26/28
安全声明 13-45
RIDADR UN 1544 6.1/PG 1
WGK德国 3
RTECS GH0700000