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中文名称英文名称CAS 编号规格目录价所属品牌订货号
槲皮素(二水)Quercetin dihydrate6151-25-310G¥343.00BSZHQ51671
槲皮素(二水)Quercetin dihydrate6151-25-3100G¥1,975.00BSZHQ51671
槲皮素(二水)Quercetin dihydrate6151-25-31KG¥16,550.00BSZHQ51671
槲皮素(二水)Quercetin dihydrate6151-25-35KG¥59,300.00BSZHQ51671
品牌BSZH
产品名称 槲皮素(二水) : Quercetin dihydrate ——【产品编号:BSZH-Q51671】
CAS编号6151-25-3
别名槲皮黄素,栎精,2-(3,4-二羟苯基)-3,5,7-三羟基-4H-1-苯并吡喃-4-酮,3,3′,4′,5,7-五羟基黄酮,2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one,3,3′,4′,5,6-Pentahydroxyflavone,Quercetin-3-O-rhamnoside
级别科学级
纯度&分析≥99% (HPLC), powder
Tips槲皮素是具有抗癌活性的黄酮类化合物,是线粒体 ATP 酶和磷酸二酯酶抑制剂。
分子式 C15H10O7 · 2H2O
分子量338.27
储存条件常温避光保存。
性质
assay ≥98% (HPLC)
form powder
color yellow
mp >300 °C(lit.)
solubility 1 M NaOH: soluble50 mg/mL
原产地美国
描述

Biochem/physiol Actions

槲皮素二水合物是具有抗癌活性的黄酮类化合物。槲皮素为线粒体 ATP 酶和磷酸二酯酶抑制剂。它可抑制 PI3 激酶活性并且轻微抑制 PIP 激酶活性。槲皮素对癌细胞系具有抗增殖作用,通过 II 型雌激素受体降低癌细胞的生长,并且阻滞细胞周期晚期 G1 相中人类白血病 T 细胞。

供货状态True
参考文献

Bowman, B.J., et al., Effects of inhibitors on the plasma membrane and mitochondrial adenosine triphosphatases of Neurospora crassa. Biochim. Biophys. Acta 512, 13-28, (1978)

Beretz, A., et al., Flavonoid compounds are potent inhibitors of cyclic AMP phosphodiesterase. Experientia 34, 1054, (1978)

Singhal, R.L., et al., Quercetin down-regulates signal transduction in human breast carcinoma cells. Biochem. Biophys. Res. Commun. 208, 425-431, (1995)

Yeh, Y.A., et al., Quercetin: synergistic action with carboxyamidotriazole in human breast carcinoma cells. Life Sci. 57, 1285-1292, (1995)

Yoshida, M., et al., Quercetin arrests human leukemic T-cells in late G1 phase of the cell cycle. Cancer Res., (1992)

Lamson, D.W., and Brignall, M.S., Antioxidants and cancer, part 3: quercetin. Altern. Med. Rev. 5, 196-208, (2000)

Roche, M., et al., Effects Of Nutritional Antioxidants On AAPH- Or AGEs-induced Oxidative Stress In Human SW872 Liposarcoma Cells. Cell Biol. Toxicol. 25, 635-44, (2009)

Gitzinger, M., et al., Controlling Transgene Expression In Subcutaneous Implants Using A Skin Lotion Containing The Apple Metabolite Phloretin. Proc. Natl. Acad. Sci. U. S. A. 106, 10638-43, (2009)

Baran, I., et al., Effects Of Menadione, Hydrogen Peroxide, And Quercetin On Apoptosis And Delayed Luminescence Of Human Leukemia Jurkat T-cells. Cell Biochem. Biophys. 58, 169-79, (2010)

Merck 14,8034

Beil. 18,V,5,494

Aldrich MSDS 1, 1577:B / Corp MSDS 1 (2), 3019:D / FT-IR 2 (2), 2509:C / FT-IR 1 (2), 96:B / FT-NMR 1 (2), 920:B / IR-Spectra (3), 906:F / IR-Spectra (2), 793:D / NMR-Reference 2 (2), 98:D / RegBook 1 (2), 1697:K / Sigma FT-IR 1 (2), 877:C / Structure Index 1, 270:D:1

类型BSZH 生物化学研究
安全信息
符号 GHS06
信号词 Danger
危险声明 H301
警示性声明 P301 + P310
个人防护装备 Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
危害码 T
风险声明 25
安全声明 45
RIDADR UN 2811 6.1/PG 3
WGK德国 3
RTECS LK8950000