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中文名称英文名称CAS 编号规格目录价所属品牌订货号
抑肽酶Aprotinin from bovine lung9087-70-11MG¥228.00SIGMAA1153
抑肽酶Aprotinin from bovine lung9087-70-15MG¥422.00SIGMAA1153
抑肽酶Aprotinin from bovine lung9087-70-125MG¥1,158.00SIGMAA1153
抑肽酶Aprotinin from bovine lung9087-70-1100MG¥4,585.00SIGMAA1153
抑肽酶Aprotinin from bovine lung9087-70-1250MG¥8,848.00SIGMAA1153
品牌SIGMA
产品名称 抑肽酶 : Aprotinin from bovine lung ——【产品编号:SIGMA-A1153】
CAS编号9087-70-1
别名Trasylol
级别科学级
纯度&分析lyophilized powder, 3-8 TIU/mg solid
Tips来源于牛肺(from bovine lung)。
分子式 C284H432N84O79S7
分子量6511.44
储存条件2-8 °C 冷藏保存。
性质
form lyophilized powder
mol wt mol wt ~6,500
solubility H2O: >10 mg/mL
storage temp. 2-8°C
原产地美国
描述

Analysis Note

另一个常用的活性单位是 KIU(激肽释放酶抑制剂单位)。
1 TIU ∼ 1,300 KIU。

Unit Definition

One trypsin inhibitor unit (TIU) will decrease the activity of 2 trypsin units by 50% where one trypsin unit will hydrolyze 1.0 μmole of N-α-benzoyl-DL-arginine p-nitroanilide (BAPNA) per min at pH 7.8 at 25 °C.

Biochem/physiol Actions

Aprotinin is a competitive serine protease inhibitor that inhibits trypsin, chymotrypsin, kallikrein and plasmin. Aprotinin forms stable complexes with and blocks the active sites of enzymes. Binding is reversible with most aprotinin-protease complexes dissociating at pH >10 or < 3. Effective concentration equimolar with protease.

General description

抑肽酶是一种由 58 个氨基酸组成的蛋白质,排列在一条与三个二硫键桥交联的多肽链上。

供货状态True
参考文献

Hansen, A., et al., Development Of A Drug Screening Platform Based On Engineered Heart Tissue. Circ. Res. 107, 35-44, (2010)

Zallocchi, M., et al., Biochemical Characterization Of Native Usher Protein Complexes From A Vesicular Subfraction Of Tracheal Epithelial Cells. Biochemistry 49, 1236-47, (2010)

Shin, Y.P., et al., Antimicrobial Activity Of A Halocidin-derived Peptide Resistant To Attacks By Proteases. Antimicrob. Agents Chemother. 54, 2855-66, (2010)

Banaszynski, L.A., et al., Analysis Of Histones And Chromatin In Xenopus Laevis Egg And Oocyte Extracts. Methods 51, 3-10, (2010)

Slobodin, B., and Gerst, J.E., RaPID: An Aptamer-based MRNA Affinity Purification Technique For The Identification Of RNA And Protein Factors Present In Ribonucleoprotein Complexes. Methods Mol. Biol. 714, 387-406, (2011)

Trautschold, I., et al. Biochem. Pharmacol. 16, 59, (1967)

Deutscher, M.P., Maintaining protein stability. Meth. Enzymol. 182, 83-89, (1990)

Dignam, J.D., Preparation of extracts from higher eukaryotes. Meth. Enzymol. 182, 194-203, (1990)

Gebhard, W., Review: Biochemistry of aprotinin and aprotinin-like inhibitors. Res. Monogr. Cell Tissue Physiol. 12, 375, (1986)

McEvoy, M.D., et al., Aprotinin in cardiac surgery: a review of conventional and novel mechanisms of action Anesth. Analg. 105, 949-962, (2007)

Aprotinin in perspective, Aprotinin in perspective Ann. Thorac. Surg. 55(4), 1033-1041, (1993)

, Beynon, R.J. and Bond, J.S., ed. Proteolytic Enzymes: A Practical Approach, (1989), 247

Merck 14,757

类型酶 & 辅酶
安全信息
个人防护装备 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
安全声明 22
WGK德国 1
RTECS YN5080000