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中文名称英文名称CAS 编号规格目录价所属品牌订货号
先锋霉素Cephalothin sodium salt58-71-9100MG¥436.00SIGMAC4520
先锋霉素Cephalothin sodium salt58-71-91G¥1,209.00SIGMAC4520
先锋霉素Cephalothin sodium salt58-71-95G¥4,161.00SIGMAC4520
先锋霉素Cephalothin sodium salt58-71-9100G¥53,200.00SIGMAC4520
品牌SIGMA
产品名称 先锋霉素 : Cephalothin sodium salt ——【产品编号:SIGMA-C4520】
CAS编号58-71-9
别名头孢噻吩钠盐,头孢菌素钠盐,头孢金素,先锋霉素钠盐,头孢霉素钠盐,7-(2-Thienylacetamido)cephalosporanic acid sodium salt,Cephalotin sodium salt
级别科学级
纯度&分析96.0-101.0%
Tips一种常用的研究级抗生素类制品,适用于科学研究、辅料、规模化生产等。
分子式 C16H15N2NaO6S2
分子量418.42
储存条件2-8 °C 冷藏保存。
性质
Appearance (Color) White to Off-White
Appearance (Form) Powder
Solubility (Color) Colorless to Light Yellow
Solubility (Turbidity) Clear
  50 mg/mL, H2O
Infrared spectrum Conforms to Structure
Assay 96.0 - 101.0 %
原产地美国
描述

Biochem/physiol Actions

Cephalothin is a first-generation cephalosporin antibiotic that disrupts the synthesis of the peptidoglycan layer of bacterial cell walls. It is effective against gram-positive and gram-negative bacteria. Mode of Resistance: Cephalosporinase production.

Mode of Action: Inhibits cell wall synthesis.
Antimicrobial spectrum: Gram-positive cocci.
Mode of Resistance: Cephalosporinase production.

Other Notes

First generation cephalosporin antibiotic.

Application

Cephalothis is used to study the mechanism of liposome encapsulated antibiotics 1, strategies for co-opting β-lactamases of Gram-negative bacteria for treatment of antibiotics 2, and for immunology studies in relation to antibiotics 3. It is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP6 on bacterial cell wall mucopeptide synthesis.

供货状态True
参考文献

1. James V. Desiderio and S. Gordon Campbell, Intraphagocytic Killing of Salmonella typhimurium by Liposome-Encapsulated Cephalothin. J. Infect. Dis. 148, 563-570, (1983)

2. S Mobashery and M Johnston, Reactions of Escherichia coli TEM β-lactamase with cephalothin and with C10-dipeptidyl cephalosporin esters. J. Biol. Chem. 261, 7879-7887, (1986)

3. Peter Spath, George Garratty, et al., Studies on the Immune Response to Penicillin and Cephalothin in Humans: I. Optimal Conditions for Titration of Hemagglutinating Penicillin and Cephalothin Antibodies. J. Immunol. 107, 854-859, (1971)

Merck 14,1982

类型抗生素
安全信息
符号 GHS08
信号词 Danger
危险声明 H317-H334
警示性声明 P261-P280-P342 + P311
个人防护装备 dust mask type N95 (US), Eyeshields, Faceshields, Gloves
危害码 Xn
风险声明 42/43
安全声明 22-36/37
WGK德国 2
RTECS XI0388300