Biochem/physiol Actions

Selective serotonin reuptake inhibitor; antidepressant.

Legal Information

Sold under license from Eli Lilly and Company.

Prozac is a registered trademark of Eli Lilly and Co.

Platelet-derived growth factor and reactive oxygen species (ROS) regulate Ras protein levels in primary human fibroblasts via ERK1/2. Amplification of ROS and Ras in systemic sclerosis fibroblasts. Svegliati S, et. al. J. Biol. Chem., 36474-82, (2005)

The serotonin transporter (SLC6A4) is present in B-cell clones of diverse malignant origin: probing a potential anti-tumor target for psychotropics. Meredith EJ, et. al. FASEB J., 1187-9, (2005)

Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor. Deecher DC, Beyer CE, Johnston G, Bray J, Shah S, Abou-Gharbia M, Andree TH J. Pharmacol. Exp. Ther., 657-65, (2006)

Characterization of single channel currents from primary cilia of renal epithelial cells. Raychowdhury MK, McLaughlin M, Ramos AJ, Montalbetti N, Bouley R, Ausiello DA, Cantiello HF J. Biol. Chem., 34718-22, (2007)

Lipid bodies are reservoirs of cyclooxygenase-2 and sites of prostaglandin-E2 synthesis in colon cancer cells. Accioly MT, et. al. Cancer Res., 1732-40, (2008)

Local suppression of Epstein-Barr virus (EBV)-specific cytotoxicity in biopsies of EBV-positive Hodgkin's disease. Frisan T, et. al. Blood, 1493-501, (2008)

AQP2 exocytosis in the renal collecting duct -- involvement of SNARE isoforms and the regulatory role of Munc18b. Procino G, Barbieri C, Tamma G, De Benedictis L, Pessin JE, Svelto M, Valenti G J. Cell Sci., 2097-106, (2008)

Chronic fenfluramine administration increases plasma serotonin (5-hydroxytryptamine) to nontoxic levels. Zolkowska D, Baumann MH, Rothman RB J. Pharmacol. Exp. Ther., 791-7, (2008)

Novel Control By The CA3 Region Of The Hippocampus On Neurogenesis In The Dentate Gyrus Of The Adult Rat. Liu, J.X., et al. PLoS ONE 6, e17562, (2011)

Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication. Wong, D.T., et al. Life Sci. 57, 411-441, (1995)

Blockage of 5HT_2C serotonin receptors by fluoxetine (Prozac). Ni, Y.G., et al. Proc. Natl. Acad. Sci. U. S. A. 94, 2036-2040, (1997)

Potentiation of the fluoxetine-induced increase in dialysate levels of serotonin (5-HT) in the frontal cortex of freely moving rats by combined blockade of 5-HT_1A and 5-HT_1B receptors with WAY 100,365 and GR 127,935. Gobert, A., et al. J. Neurochem. 68, 1159-1163, (1997)

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