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中文名称英文名称CAS 编号规格目录价所属品牌订货号
氨甲喋呤Methotrexate hydrate133073-73-110MG¥455.00SIGMAA6770
氨甲喋呤Methotrexate hydrate133073-73-1100MG¥1,188.00SIGMAA6770
氨甲喋呤Methotrexate hydrate133073-73-1500MG¥5,627.00SIGMAA6770
氨甲喋呤Methotrexate hydrate133073-73-11G¥9,711.00SIGMAA6770
品牌SIGMA
产品名称 氨甲喋呤 : Methotrexate hydrate ——【产品编号:SIGMA-A6770】
CAS编号133073-73-1
别名对-[(2,4-二氨基喋啶-6)-N-甲基甲氨基]苯甲酰谷氨酸水合物,L-氨甲喋呤 水合物,MTX水合物,氟安定水合物,氨甲叶酸水合物,氨甲喋呤水合物,甲氨蝶呤水合物,amethopterin,methotrexate
级别科学级
纯度&分析≥98% (HPLC), powder
Tips叶酸拮抗剂,二氢叶酸还原酶(dihydrofolate reductase)抑制剂。
分子式 C20H22N8O5 · xH2O
分子量454.44 (anhydrous basis)
储存条件-20 °C 低温冷冻保存。
性质
assay ≥98% (HPLC)
form powder
color yellow
solubility H2O: insoluble
storage temp. −20°C
原产地美国
描述

Application

Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.4

Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.

供货状态True
参考文献

1. Sasso, S.P., et al. Biochim. Biophys. Acta 1207, 74, (1994)

2. Huennekens, F.M. Adv. Enzyme Regul. 34, 397, (1994)

3. Nagy, A., et al. Proc. Natl. Acad. Sci. U. S. A. 90, 6373, (1993)

4. Imwong, M., et al., Methotrexate Is Highly Potent Against Pyrimethamine-Resistant Plasmodium vivax J. Infect. Dis. 203, 207-210, (2011)

Merck 14,5985

Aldrich MSDS 1, 55:A / Corp MSDS 1 (1), 129:C / FT-IR 1 (2), 898:D / FT-IR 2 (3), 3973:C / IR-Spectra (3), 1416:H / Sax 6, 1767 / Sigma FT-IR 1 (2), 252:A / Structure Index 1, 419:D:1

类型核酸 & 衍生物
安全信息
符号 GHS06GHS08
信号词 Danger
危险声明 H301-H315-H319-H360
警示性声明 P201-P301 + P310-P305 + P351 + P338-P308 + P313
个人防护装备 Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
危害码 T
风险声明 61-25-36/38
安全声明 53-26-36/37-45
RIDADR UN 1544 6.1/PG 3
WGK德国 3