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中文名称英文名称CAS 编号规格目录价所属品牌订货号
蛋白酶抑制剂(抑肽酶)Aprotinin from bovine lung9087-70-11MG562.00SIGMAA6106
蛋白酶抑制剂(抑肽酶)Aprotinin from bovine lung9087-70-15MG1,753.00SIGMAA6106
蛋白酶抑制剂(抑肽酶)Aprotinin from bovine lung9087-70-125MG3,016.00SIGMAA6106
蛋白酶抑制剂(抑肽酶)Aprotinin from bovine lung9087-70-1100MG10,366.00SIGMAA6106
品牌SIGMA
产品名称 蛋白酶抑制剂(抑肽酶) : Aprotinin from bovine lung ——【产品编号:SIGMA-A6106】
CAS编号9087-70-1
别名Trasylol 蛋白酶抑制剂(碱性),Trypsin inhibitor (basic)
级别科学级
纯度&分析BioUltra, ≥4 TIU/mg solid, ≥98% (SDS-PAGE)
Tips来源于牛肺。
分子式 C284H432N84O79S7
分子量6511.44
储存条件2-8 °C 冷藏保存。
性质
Related Categories Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Type, Enzymes, Inhibitors, and Substrates, Proteins
Quality Level PREMIUM
product line BioUltra
assay ≥98% (SDS-PAGE)
mol wt mol wt ~6,500
storage temp. 2-8°C
原产地美国
描述

Analysis Note

另一个常用的活性单位是 KIU(激肽释放酶抑制剂单位)。
1 TIU ∼ 1,300 KIU。

Preparation Note

A further purification of A1153 to yield a product with slightly higher activity and purity.

Unit Definition

One trypsin inhibitor unit (TIU) will decrease the activity of 2 trypsin units by 50% where one trypsin unit will hydrolyze 1.0 μmole of N-α-benzoyl-DL-arginine p-nitroanilide (BAPNA) per min at pH 7.8 at 25 °C.

Biochem/physiol Actions

Aprotinin is a nonspecific serine protease inhibitor extracted from bovine lung. Aprotinin blocks contact activation of the kallekrein system during cardiopulmonary bypass and in synergy with heparin prevents thrombin formation through inhibition of the intrinsic clotting cascade.1

Aprotinin is a competitive serine protease inhibitor that inhibits trypsin, chymotrypsin, kallikrein and plasmin. Aprotinin forms stable complexes with and blocks the active sites of enzymes.

General description

抑肽酶是一种由 58 个氨基酸组成的蛋白质,排列在一条与三个二硫键桥交联的多肽链上。

供货状态True
参考文献

1. Aprotinin in perspective, Aprotinin in perspective Ann. Thorac. Surg. 55(4), 1033-1041, (1993)

Dignam, J.D., Preparation of extracts from higher eukaryotes. Meth. Enzymol. 182, 194-203, (1990)

Trautschold, I., et al. Biochem. Pharmacol. 16, 59, (1967)

Deutscher, M.P., Maintaining protein stability. Meth. Enzymol. 182, 83-89, (1990)

Gebhard, W., Review: Biochemistry of aprotinin and aprotinin-like inhibitors. Res. Monogr. Cell Tissue Physiol. 12, 375, (1986)

McEvoy, M.D., et al., Aprotinin in cardiac surgery: a review of conventional and novel mechanisms of action Anesth. Analg. 105, 949-962, (2007)

, Beynon, R.J. and Bond, J.S., ed. Proteolytic Enzymes: A Practical Approach, (1989), 247

Merck 14,757

类型酶 & 辅酶
安全信息
个人防护装备 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
安全声明 22
WGK德国 1
RTECS YN5080000