Biochem/physiol Actions

The acute toxicity of aniline involves its activation in vivo to 4-hydroxyaniline and the formation of adducts with hemoglobin. In erythrocytes, this is associated with the release of iron and the accumulation of methemoglobin and the development of hemolytic anemia and inflammation of the spleen. Tumor formation is often observed in the spleen on prolonged administration.

Physical properties

材料在储存期间颜色变暗，成为红棕色，但纯度不会受到​影响。

法律信息

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High-Density Real-Time PCR-Based in vivo Toxicogenomic Screen to Predict Organ-Specific Toxicity. Gabriella Fabian et al Int. J. Mol. Sci. 12, 6116-34, (2011)

Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Giulia Caron et al J. Med. Chem. 48, 3269-79, (2005)

QSAR study on permeability of hydrophobic compounds with artificial membranes. Masaaki Fujikawa et al Bioorg. Med. Chem. 15, 3756-67, (2007)

The many roles for fluorine in medicinal chemistry. William K Hagmann et al J. Med. Chem. 51, 4359-69, (2008)

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Lourdes Santana et al J. Med. Chem. 51, 6740-51, (2008)

Convenient QSAR model for predicting the complexation of structurally diverse compounds with beta-cyclodextrins. Alfonso Pérez-Garrido et al Bioorg. Med. Chem. 17, 896-904, (2009)

Aryl H-phosphonates 17: (N-aryl)phosphoramidates of pyrimidine nucleoside analogues and their synthesis, selected properties, and anti-HIV activity. Joanna Romanowska et al J. Med. Chem. 54, 6482-91, (2011)

QSAR study and synthesis of new phenyltropanes as ligands of the dopamine transporter (DAT). Sylvie Mavel et al Bioorg. Med. Chem. 20, 1388-95, (2012)

Biomonitoring of aromatic amines VI: determination of hemoglobin adducts after feeding aniline hydrochloride in the diet of rats for 4 weeks. Zwirner-Baier, I., et al. Arch. Toxicol. 77, 672-67, (2003)

Hemolytic drugs aniline and dapsone induce iron release in erythrocytes and increase the free iron pool in spleen and liver. Ciccoli, L., et al. Toxicol. Lett. 110, 57-66, (1999)

Merck 14,659

Beil. 12,IV,223

Fieser 6,21

Aldrich MSDS 1, 125:D / Corp MSDS 1 (1), 270:A / FT-IR 1 (1), 1189:A / FT-IR 2 (2), 2024:A / FT-NMR 1 (2), 451:A / IR-Spectra (2), 630:A / IR-Spectra (3), 714:A / NMR-Reference 2 (1), 987:A / RegBook 1 (1), 1383:A / Sax 6, 280 / Sigma FT-IR 1 (2), 284:A / Structure Index 1, 214:A:1 / Vapor Phase 3, 1109:A