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中文名称英文名称CAS 编号规格目录价所属品牌订货号
罗格列酮Rosiglitazone122320-73-410MG694.00SIGMAR2408
罗格列酮Rosiglitazone122320-73-450MG2,972.00SIGMAR2408
罗格列酮Rosiglitazone122320-73-41G31,500.00SIGMAR2408
品牌SIGMA
产品名称 罗格列酮 : Rosiglitazone ——【产品编号:SIGMA-R2408】
CAS编号122320-73-4
别名5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
级别科学级
纯度&分析≥98% (HPLC)
Tips一种噻唑烷二酮类抗糖尿病化学原料药。
分子式 C18H19N3O3S
分子量357.43
储存条件2-8 °C 冷藏保存。
性质
Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Gene Regulation and Expression,
GlaxoSmithKline, PPAR and RXR Regulators
assay ≥98% (HPLC)
  ≥98% (HPLC)
form powder
solubility DMSO: ≥10 mg/mL
storage temp. 2-8°C
原产地美国
描述

Biochem/physiol Actions

Rosiglitazone is a potent agonist for PPARγ with an EC50 of 43 nM for the human receptor. It is antidiabetic, working as an insulin sensitizer by binding to the PPARγ receptors in fat cells and making the cells more responsive to insulin.

供货状态True
参考文献

Millar JS, Ikewaki K, Bloedon LT, Wolfe ML, Szapary PO, Rader DJ, Effect of rosiglitazone on HDL metabolism in subjects with metabolic syndrome and low HDL J. Lipid Res. 1, 136-42, (2011)

Tang Wei, Zeve Daniel, Seo Jin, Jo A-Young, Graff Jonathan M., Thiazolidinediones Regulate Adipose Lineage Dynamics Cell Metab. 14, 116-22, (2011)

Ryan MJ, Didion SP, Mathur S, Faraci FM, Sigmund CD, PPAR(gamma) agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice Hypertension 3, 661-6, (2004)

类型BSZH 生物化学研究
安全信息
WGK德国 3