» 产品价格(Market Price)⇒ 联系客服 +
中文名称英文名称CAS 编号规格目录价所属品牌订货号
维生素 B12Vitamin B1268-19-9250MG496.00SIGMAV2876
维生素 B12Vitamin B1268-19-91G994.00SIGMAV2876
维生素 B12Vitamin B1268-19-95G2,870.00SIGMAV2876
维生素 B12Vitamin B1268-19-925G12,900.00SIGMAV2876
品牌SIGMA
产品名称 维生素 B12 : Vitamin B12 ——【产品编号:SIGMA-V2876】
CAS编号68-19-9
别名维他命B12,氰基钴胺,氰钴胺,α-(5,6-Dimethylbenzimidazolyl)cyanocobamide,CN-Cbl,Cyanocob(III)alamin
级别科学级
纯度&分析≥98.5%
Tips常用的维生素类制品,可用作相关生化研究。
分子式 C63H88CoN14O14P
分子量1355.37
储存条件2-8 °C 冷藏保存。
性质
Related Categories Biochemicals and Reagents, Cofactors, Enzymes, Inhibitors, and Substrates, Nutrition Research, Other Cofactors,
Panax ginseng, Phytochemicals by Plant (Food/Spice/Herb), Vitamin B, Vitamin B12, Vitamins
assay   ≥98.5%
storage temp.   2-8°C
原产地美国
描述

Biochem/physiol Actions

Vitamin B12 (cobalamin) refers to a group of chemically-related cobalt containing molecules involved in cell processes such as DNA synthesis, fatty acid synthesis, energy production and regulation. The physiologically active forms of vitamin B12 include methylcobalamin and adenosylcobalamin, whereas hydroxocobalamin (vitamin B12a, OHCbl) and cyanocobalamin (CNCbl) are storage and delivery forms. Bacteria-derived hydroxocobalamin (OHCbl) and CNCbl are converted in humans to useful coenzyme forms to support metabolic processes such as mitochondrial methylmalonylcoenzyme A mutase conversion of methylmalonic acid (MMA) to succinate to link lipid and carbohydrate metabolism, and activation of methionine synthase, the rate limiting step in the synthesis of methionine.

供货状态True
参考文献

Senisterra, G.A., et al., Assessing The Stability Of Membrane Proteins To Detect Ligand Binding Using Differential Static Light Scattering. J. Biomol. Screen. 15, 314-20, (2010)

Folmsbee, M.J., et al., Anaerobic Growth of Bacillus mojavensis and Bacillus subtilis Requires Deoxyribonucleosides or DNA Appl. Environ. Microbiol. 70, 5252-7, (2004)

Vedadi, M., et al., Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination Proc. Natl. Acad. Sci. U. S. A. 103, 15835-40, (2006)

Yamanishi M, Vlasie M, Banerjee R., Adenosyltransferase: an enzyme and an escort for coenzyme B12? Trends Biochem. Sci. 30, 304-308, (2005)

Banerjee R., B12 trafficking in mammals: A for coenzyme escort service. ACS Chem. Biol. 1, 149-159, (2006)

Kim J, Hannibal L, Gherasim C, et al., A human vitamin B12 trafficking protein uses glutathione transferase activity for processing alkylcobalamins. J. Biol. Chem. 284, 33418-33424, (2009)

Hannibal L, Kim J, Brasch NE, Wang S, et al., Processing of alkylcobalamins in mammalian cells: A role for the MMACHC (cblC) gene product. Mol. Genet. Metab. 97, 260-266, (2009)

Koutmos M, Gherasim C, Smith JL, Banerjee R., Structural basis of multifunctionality in a vitamin B12-processing enzyme. J. Biol. Chem. 286, 29780-29787, (2011)

Gruber K, Puffer B, Kräutler B., Vitamin B12-derivatives-enzyme cofactors and ligands of proteins and nucleic acids. Chem. Soc. Rev. 40, 4346-4363, (2011)

Merck 14,10014

Beil. 26,IV,3117

类型维生素
安全信息
个人防护装备  Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
安全声明  22-24/25
WGK德国  1
RTECS  GG3750000