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中文名称英文名称CAS 编号规格目录价所属品牌订货号
5'-三磷酸鸟苷钠盐(GTP)Guanosine 5′-triphosphate sodium salt hydrate36051-31-710MG343.00SIGMAG8877
5'-三磷酸鸟苷钠盐(GTP)Guanosine 5′-triphosphate sodium salt hydrate36051-31-725MG595.00SIGMAG8877
5'-三磷酸鸟苷钠盐(GTP)Guanosine 5′-triphosphate sodium salt hydrate36051-31-7100MG1,402.00SIGMAG8877
5'-三磷酸鸟苷钠盐(GTP)Guanosine 5′-triphosphate sodium salt hydrate36051-31-7250MG2,344.00SIGMAG8877
5'-三磷酸鸟苷钠盐(GTP)Guanosine 5′-triphosphate sodium salt hydrate36051-31-71G6,674.00SIGMAG8877
品牌SIGMA
产品名称 5'-三磷酸鸟苷钠盐(GTP) : Guanosine 5′-triphosphate sodium salt hydrate ——【产品编号:SIGMA-G8877】
CAS编号36051-31-7
别名GTP,鸟苷-5′-三磷酸钠盐,GTP钠盐
级别科学级
纯度&分析≥95% (HPLC), powder
Tips一种常见的核酸类衍生物。
分子式C10H16N5O14P3 · xNa+
分子量523.18 (free acid basis)
储存条件-20 °C 低温冷冻保存。
性质
Related Categories Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cofactors, Enzyme Substrates, Enzymes, Inhibitors, and Substrates, G, G Protein Function, G Proteins and Cyclic Nucleotides, GTPase, Metabolic Pathways, Metabolites and Cofactors on the Metabolic Pathways Chart, Metabolomics, Nucleotide, Phosphate Donors, Reagents, Substrates by Enzyme, TCA
assay ≥95% (HPLC)
form powder
color white
solubility H2O: soluble50 mg/mL
shipped in dry ice
storage temp. −20°C
原产地美国
描述

Preparation Note

Prepared by enzymatic phosphorylation of 5′-GMP.

Biochem/physiol Actions

GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.

供货状态True
参考文献

Geiger, J.E., et al., Ca2+ Entry Through A Non-selective Cation Channel In Aplysia Bag Cell Neurons. Neuroscience 162, 1023-38, (2009)

Rao, F., et al., Enzymatic Synthesis Of C-di-GMP Using A Thermophilic Diguanylate Cyclase. Anal. Biochem. 389, 138-42, (2009)

Judkewitz, B., et al., Targeted Single-cell Electroporation Of Mammalian Neurons In Vivo. Nat. Protoc. 4, 862-9, (2009)

Takai, K., et al., Practical Cell-free Protein Synthesis System Using Purified Wheat Embryos. Nat. Protoc. 5, 227-38, (2010)

Dreier, B., and Plückthun, A., Ribosome Display: A Technology For Selecting And Evolving Proteins From Large Libraries. Methods Mol. Biol. 687, 283-306, (2011)

Gutkind, J.S., Cell growth control by G protein-coupled receptors: from signal transduction to signal integration. Oncogene 17, 1331-1342, (1998)

Dhanasekaran, N., et al., Regulation of cell proliferation by G proteins. Oncogene 17, 1383-1394, (1998)

Hepler, J.R., and Gilman, A.G., G proteins. Trends Biochem. Sci. 17, 383-387, (1992)

Gomez, J., et al., Dual role of Ras and Rho proteins: at the cutting edge of life and death. Immunol. Cell Biol. 76, 125-134, (1998)

Lacal, J.C., Regulation of proliferation and apoptosis by Ras and Rho GTPases through specific phospholipid-dependent signaling. FEBS Lett. 410, 73-77, (1997)

Schimmoller, F., et al., Rab GTPases, directors of vesicle docking. J. Biol. Chem. 273, 22161-22164, (1998)

Woodman, P., Vesicle transport: more work for the Rabs?. Curr. Biol. 8, R199-R201, (1998)

类型核酸 & 衍生物
安全信息
个人防护装备 Eyeshields, Faceshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
危害码 T
风险声明 36/37/38-39/23/24/25
安全声明 26-36/37/39-45
WGK德国 3