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中文名称英文名称CAS 编号规格目录价所属品牌订货号
氯丙嗪盐酸盐Chlorpromazine hydrochloride69-09-05G¥897.00SIGMAC8138
氯丙嗪盐酸盐Chlorpromazine hydrochloride69-09-025G¥3,593.00SIGMAC8138
氯丙嗪盐酸盐Chlorpromazine hydrochloride69-09-0100G¥8,922.00SIGMAC8138
氯丙嗪盐酸盐Chlorpromazine hydrochloride69-09-01KG¥57,100.00SIGMAC8138
品牌SIGMA
产品名称 氯丙嗪盐酸盐 : Chlorpromazine hydrochloride ——【产品编号:SIGMA-C8138】
CAS编号69-09-0
别名2-氯-10-(3-二甲氨基丙基)吩噻嗪盐酸盐,CPZ,氯普马嗪,盐酸氯丙嗪,冬眠灵,可乐静,阿米那嗪,wintermine
级别科学级
纯度&分析≥98% (TLC)
Tips在血红蛋白和过氧化物酶的微量测定中替代联苯胺、邻联茴香胺和邻联甲苯胺。
分子式 C17H19ClN2S · HCl
分子量355.33
储存条件常温避光保存。
性质

Chlorpromazine is a compound that is used in cell signaling and neuroscience research. It is a dopamine inhibitor, notably at the D2-dopaminergic receptor. It also has a-adrenergic blocking activity and stimulates prolactin release. The antifungal properties of chlorpromazine and other compounds has been reviewed. The role of chlorpromazine and other tricyclic compounds as inhibitors of neuronal voltagegated K channels has been discussed.


The use of chlorpromazine (0 - 0.2 mM) to induce stress in E. coli to study regulation of the RcsCB His-Asp phosphorelay system has been described. The effect of chlorpromazine (1 mM) and other dopamine-active drugs on the production of oxytocin and vasopressin in rat neurohypophyseal tissue cultures has been studied. Chlorpromazine has been used to probe long-term potentiation of corticostriatal synaptic transmission in rat. Chlorpromazine (12 or 25 mM) has been shown to limit lipid accumulation in the human breast cell line HBL-100, as initially induced by tetraphenylphosphonium chloride.


An analytical method for chlorpromazine that couples high performance liquid chromatography to inductively coupled plasma mass spectroscopy has been described.

原产地美国
描述

Application

在血红蛋白和过氧化物酶的微量测定中替代联苯胺、邻联茴香胺和邻联甲苯胺。

Biochem/physiol Actions

吩噻嗪类抗精神病药;D2 多巴胺受体拮抗剂,H1 组胺受体拮抗剂;抑制钙调蛋白依赖性环核苷酸磷酸二酯酶和一氧化氮合成酶的活化。

氯丙嗪表现出对白血病细胞的细胞毒性和抗增殖活性,但是不会影响正常淋巴细胞的活力。

供货状态True
参考文献

Heikkila, O., et al., Internalization of Coxsackievirus A9 Is Mediated by {beta}2-Microglobulin, Dynamin, and Arf6 but Not by Caveolin-1 or Clathrin J. Virol. 84, 3666-81, (2010)

Heikkilä, O., et al., Internalization Of Coxsackievirus A9 Is Mediated By β2-Microglobulin, Dynamin, And Arf6 But Not By Caveolin-1 Or Clathrin J. Virol. 84, 3666-3681, (2010)

Fernandez-Garcia, M.D., et al., Appraising The Roles Of CBLL1 And The Ubiquitin/Proteasome System For Flavivirus Entry And Replication. J. Virol. 85, 2980-9, (2011)

Li, Y., et al., Quantum Dot-antisense Oligonucleotide Conjugates For Multifunctional Gene Transfection, MRNA Regulation, And Tracking Of Biological Processes. Biomaterials 32, 1923-31, (2011)

Collier, H.B. Clin. Biochem. 7, 331, (1974)

Palacios, M., et al. Biochem. Biophys. Res. Commun. 196, 280, (1993)

Merck 14,2185

Beil. 27,IV,1300

类型BSZH 生物化学研究
安全信息
符号 GHS06
信号词 Danger
危险声明 H301-H330
警示性声明 P260-P284-P301 + P310-P310
个人防护装备 Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
危害码 T+
风险声明 25-26
安全声明 28-36/37-45
RIDADR UN 2811 6.1/PG 1
WGK德国 3
RTECS SO1750000