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中文名称英文名称CAS 编号规格目录价所属品牌订货号
D-泛酸钙D-Pantothenic acid hemicalcium salt137-08-625G264.00SIGMAP2250
D-泛酸钙D-Pantothenic acid hemicalcium salt137-08-6100G546.00SIGMAP2250
D-泛酸钙D-Pantothenic acid hemicalcium salt137-08-6500G1,790.00SIGMAP2250
品牌SIGMA
产品名称 D-泛酸钙 : D-Pantothenic acid hemicalcium salt ——【产品编号:SIGMA-P2250】
CAS编号137-08-6
别名D-泛酸半钙盐,(R)-(+)-N-(2,4-二羟基-3,3-二甲基-1-氧代丁基)-β-丙氨酸 半钙盐,D-泛酸钙,维生素 B5
级别科学级
纯度&分析≥98% (TLC)
Tips即:维生素 B5,生物合成辅酶A的前提物质,由于泛酸的易潮解等不稳定特性,故用钙盐作替代物。
分子式 HOCH2C(CH3)2CH(OH)CONHCH2CH2CO2 ·1/2Ca
分子量238.27
储存条件2-8 °C 冷藏保存。
性质
Appearance (Color) White to Off-White
Appearance (Form) Powder
Solubility (Color) Colorless
Solubility (Turbidity) Clear
  50 mg/ml, H2O
Purity (TLC) ≥98 %
Specific Rotation (anhydrous) 25.0 - 27.5 °
  C = 5 in Water
Water (by LOD) ≤5.0 %
Nitrogen (dry basis) 5.7 - 6.0 %
Calcium (Ca) 8.2 - 8.6 %
  Dry Basis
Infrared spectrum Conforms to Structure
原产地美国
描述

Application

生物合成辅酶 A 的前体。

Biochem/physiol Actions

D-Panthenol is the alcohol analogue and biological precursor of D-pantothenic acid. These analogues are precursors in the biosynthesis of coenzyme A. D-Panthenol and D-Pantothenic acid are used in a variety of skin protection products. D-pantothenic acid may have a role in controlling keratinocyte proliferation and differentiation. D-Panthenol may be used for studies of skin protection emulsions from UV irradiation and as a humectant.

Physical properties

由于游离酸具有不稳定性和吸湿性,因此采用钙盐的形式

供货状态True
参考文献

Folmsbee, M.J., et al., Anaerobic Growth of Bacillus mojavensis and Bacillus subtilis Requires Deoxyribonucleosides or DNA Appl. Environ. Microbiol. 70, 5252-7, (2004)

Vedadi, M., et al., Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination Proc. Natl. Acad. Sci. U. S. A. 103, 15835-40, (2006)

Obrigkeit DH, Oepen T, Jugert FK, et al., Xenobiotics in vitro: the influence of L-cystine, pantothenat, and miliacin on metabolic and proliferative capacity of keratinocytes. Cutan. Ocul. Toxicol. 25, 13-22, (2006)

Hui X, Hornby SB, Wester RC, et al., In vitro human nail penetration and kinetics of panthenol. Int. J. Cosmet. Sci. 29, 277-282, (2007)

Wiederholt T, Heise R, Skazik C, et al., Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp. Dermatol. 18, 969-978, (2009)

Zanatta CF, Mitjans M, Urgatondo V, et al., Photoprotective potential of emulsions formulated with Buriti oil (Mauritia flexuosa) against UV irradiation on keratinocytes and fibroblasts cell lines. Food Chem. Toxicol. 48, 70-75, (2010)

Kobayashi D, Kusama M, Onda M, et al., The effect of pantothenic acid deficiency on keratinocyte proliferation and the synthesis of keratinocyte growth factor and collagen in fibroblasts. J. Pharmacol. Sci. 115, 230-234, (2011)

Brown, G.M. and Williamson, M. Adv. Enzymol. 53, 345, (1982)

Merck 14,7015

Beil. 4,IV,2569

类型维生素
安全信息
个人防护装备  Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK德国  1
RTECS  RU4375000