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中文名称英文名称CAS 编号规格目录价所属品牌订货号
5-溴-2′-脱氧尿苷5-Bromo-2′-deoxyuridine59-14-3100MG¥292.00SIGMAB5002
5-溴-2′-脱氧尿苷5-Bromo-2′-deoxyuridine59-14-31G¥881.00SIGMAB5002
5-溴-2′-脱氧尿苷5-Bromo-2′-deoxyuridine59-14-35G¥3,706.00SIGMAB5002
5-溴-2′-脱氧尿苷5-Bromo-2′-deoxyuridine59-14-3100G¥57,505.00SIGMAB5002
品牌SIGMA
产品名称 5-溴-2′-脱氧尿苷 : 5-Bromo-2′-deoxyuridine ——【产品编号:SIGMA-B5002】
CAS编号59-14-3
别名5-溴-2′-脱氧脲苷,5-BrdU,5-溴-1-(2-脱氧-β-D-呋喃核糖)尿嘧啶,5-溴脱氧尿苷,BUdR
级别科学级
纯度&分析≥99% (HPLC)
Tips用作遗传研究中诱变剂的胸苷类似物,在 S 期可选择性结合到细胞 DNA 中。
分子式 C9H11BrN2O5
分子量307.10
储存条件-20 °C 低温冷冻保存。
性质
Appearance (Color) White to Off-White
Appearance (Form) Powder
Solubility (Color) Colorless to Very Faint Yellow
Solubility (Turbidity) Clear
  50 mg/mL, DMSO
EmM 8.9 - 9.2
  at pH of 1.0
Wavelength 279 - 280 nm
Purity (HPLC) ≥99 %
原产地美国
描述

Biochem/physiol Actions

用作遗传研究中诱变剂的胸苷类似物。在 S 期可选择性结合到细胞 DNA 中。

Application

5-Bromo-2′-deoxyuridine (5-BrdU) is a thymidine analogue which is incorporated into DNA. 5-BrdU is routinely and extensively used to measure DNA synthesis and to label dividing cells. Consequently 5-BrdU is used to study cell signaling and other processes that induce cell proliferation.

供货状态True
参考文献

Rizzi S, Bianchi P, Guidi S, et al., Impact of environmental enrichment on neurogenesis in the dentate gyrus during the early postnatal period. Brain Res., (2011)

Gui Y, He G, Walsh MP, Zheng XL., Signaling mechanisms mediating Up4A-induced proliferation of human vascular smooth muscle cells. J. Cardiovasc. Pharmacol. 58(6), 654-662, (2011)

Li C, Gotlieb AI., Transforming Growth Factor-β Regulates the Growth of Valve Interstitial Cells in Vitro. Am. J. Pathol. 179(4), 1746-1755, (2011)

Cifuentes M, Pérez-Martín M, et al., A comparative analysis of intraperitoneal versus intracerebroventricular administration ofbromodeoxyuridine for the study of cell proliferation in the adult rat brain. J. Neurosci. Methods 201(2), 307-314, (2011)

Boccadoro, M., et al. Tumor 72, 135, (1986)

Givan, A.L. Flow Cytometry: First Principles New York , (1992)

Merck 14,1452

Beil. 24,IV,1234

Corp MSDS 1 (1), 519:B / FT-IR 1 (2), 816:C / FT-IR 2 (3), 3842:D / FT-NMR 1 (3), 375:A / IR-Spectra (3), 1357:C / IR-Spectra (2), 1182:A / NMR-Reference 2 (2), 695:B / RegBook 1 (2), 2571:C / Sax 6, 525 / Sigma FT-IR 1 (1), 763:B / Structure Index 1, 406:A:7

类型核酸 & 衍生物
安全信息
符号 GHS08
信号词 Danger
危险声明 H340-H361
警示性声明 P201-P281-P308 + P313
个人防护装备 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK德国 2
RTECS YU7350000