» 产品价格(Market Price)⇒ 联系客服 +
中文名称英文名称CAS 编号规格目录价所属品牌订货号
细胞色素 C(源于人心脏)Cytochrome c from human heart9007-43-610UG¥7,326.00SIGMAC3483
细胞色素 C(源于人心脏)Cytochrome c from human heart9007-43-6100UG¥58,600.00SIGMAC3483
品牌SIGMA
产品名称 细胞色素 C(源于人心脏) : Cytochrome c from human heart ——【产品编号:SIGMA-C3483】
CAS编号9007-43-6
别名人细胞色素C
级别科学级
纯度&分析≥95% (SDS-PAGE), lyophilized powder
Tips细胞色素 C是一种电子负载线粒体蛋白质,是一​种通用的呼吸作用催化剂,能在呼吸底物和氧之间形成必​要的电子桥。
分子式N/A
分子量N/A
储存条件-20 °C 低温冷冻保存。
性质
assay ≥95% (SDS-PAGE)
form lyophilized powder
mol wt mol wt 11 kDa by SDS-PAGE
storage temp. −20°C
Gene Information human ... CYCS(54205), CYCSL1(157317)
原产地美国
描述

Preparation Note

Chemically oxidized during purification.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Application

Cytochrome c has been identified as an important mediator in apoptotic pathways. The release of mitochondrial cytochrome c into the cytoplasm stimulates apoptosis and is commonly used as an indicator of the apoptotic process in the cell. Investigation on the effect of Paris Saponin I (PS I) on human gastric carcinoma cell growth (SGC7901 cells) have shown an elevated level cytoplasmic cytochrome c. Results are an inhibition of proliferation in SGC7901 cells by inducing mitochondria-dependent apoptosis through cytochrome c.

Biochem/physiol Actions

The ready fluctuation of cytochrome c within the cell between ferrous and ferric states, makes it an efficient biological electron-transporter. It plays a vital role in cellular oxidations in both plants and animals. Generally regarded as a universal catalyst of respiration, it forms the essential electron-bridge between the respirable substrates and oxygen.

 

The ready fluctuation of cytochrome c within the cell between ferrous and ferric states, makes it an efficient biological electron-transporter. It plays a vital role in cellular oxidations in both plants and animals. Generally regarded as a universal catalyst of respiration, it forms the essential electron-bridge between the respirable substrates and oxygen.

In addition to its function in electron transport, cytochrome c acts as an apoptosis-triggering agent, forming the apoptosome with apoptosis protease-activating factor-1 (Apaf-1) and activating the caspase cascade. The two functions are finely tuned by phosphorylation of Tyr residues at position 48 and/or 97. One recent report provides suggestive evidence that phosphorylation at Tyr48 switches off the apoptotic effect.

供货状态True
参考文献

Paris chinensis dioscin induces G2/M cell cycle arrest and apoptosis in human gastric cancer SGC-7901 cells. Gao L., et al. World J. Gastroenterol. 17, 4389-4395, (2011)

Tyrosine phosphorylation turns alkaline transition into a biologically relevant process and makes human cytochrome c behave as an anti-apoptotic switch García-Heredia, J.M., et al. J. Biol. Inorg. Chem. 16, 1155-1168, (2011)

类型生物化学
安全信息
个人防护装备 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK德国 3
RTECS HA5365000