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中文名称英文名称CAS 编号规格目录价所属品牌订货号
亚油酸Linoleic acid60-33-31G280.00SIGMAL1376
亚油酸Linoleic acid60-33-35G724.00SIGMAL1376
亚油酸Linoleic acid60-33-325G2,826.00SIGMAL1376
品牌SIGMA
产品名称 亚油酸 : Linoleic acid ——【产品编号:SIGMA-L1376】
CAS编号60-33-3
别名罂酸,亚麻油酸,亚麻仁油酸,9-cis,12-cis-Linoleic acid, cis-9,cis-12-Octadecadienoic acid, Telfairic acid
级别科学级
纯度&分析≥99.0%
TipsLinoleic acid increases cell proliferation and gene expression of PPARα
分子式CH3(CH2)4CH=CHCH2CH=CH(CH2)7CO2H
分子量280.45
储存条件-20 °C 低温冷冻保存。
性质
assay ≥99%
refractive index n20/D 1.466(lit.)
bp 229-230 °C/16 mmHg(lit.)
mp −5 °C(lit.)
density 0.902 g/mL at 25 °C(lit.)
storage temp. −20°C
原产地美国
描述

Biochem/physiol Actions

Linoleic acid increases cell proliferation and gene expression of PPARα and its target genes such as acyl-CoA oxidase in primary duck hepatocytes 1.

Linoleic acid is an n-6 polyunsaturated essential fatty acid (PUFA) used as a precursor of arachidonic acid (AA) and various prostaglandins. Linoleic acid may be used to improve the delivery and efficacy of anticancer drugs and in cancer protection.

供货状态True
参考文献

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Pathways For The Influx Of Molecules Into Cercariae Of Schistosoma Mansoni During Skin Penetration. Thornhill, J.A., et al. Parasitology 137, 1089-98, (2010)

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Bioassay guided purification of the antimicrobial fraction of a Brazilian propolis from Bahia state. Myrella Lessio Castro et al BMC Complement Altern. Med. 9, 25, (2009)

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Synthesis and biological evaluation of 3-aryl-3-(4-phenoxy)-propionic acid as a novel series of G protein-coupled receptor 40 agonists. Fengbin Song et al J. Med. Chem. 50, 2807-17, (2007)

Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture. Masahiko Yano et al Antimicrob. Agents Chemother. 51, 2016-27, (2007)

Inhibition of hepatitis C virus replication by peroxidation of arachidonate and restoration by vitamin E. Hua Huang et al Proc. Natl. Acad. Sci. U. S. A. 104, 18666-70, (2007)

Kinetic isotope effects in the oxidation of arachidonic acid by soybean lipoxygenase-1. Cyril Jacquot et al Bioorg. Med. Chem. Lett. 18, 5959-62, (2008)

Discovery of diacylphloroglucinols as a new class of GPR40 (FFAR1) agonists. Sandip B Bharate et al Bioorg. Med. Chem. Lett. 18, 6357-61, (2008)

Bile and unsaturated fatty acids inhibit the binding of cholera toxin and Escherichia coli heat-labile enterotoxin to GM1 receptor. Arpita Chatterjee et al Antimicrob. Agents Chemother. 52, 220-4, (2008)

Substrate specificity effects of lipoxygenase products and inhibitors on soybean lipoxygenase-1. Aaron T Wecksler et al Bioorg. Med. Chem. 17, 6534-9, (2009)

Activation of PPARgamma by metabolites from the flowers of purple coneflower (Echinacea purpurea). Kathrine B Christensen et al J. Nat. Prod. 72, 933-7, (2009)

Discovery of highly selective inhibitors of human fatty acid binding protein 4 (FABP4) by virtual screening. Haiyan Cai et al Bioorg. Med. Chem. Lett. 20, 3675-9, (2010)

An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds. Yunbao Liu et al J. Nat. Prod. 73, 1193-5, (2010)

Fatty acids as natural specific inhibitors of the proto-oncogenic protein Shp2. Dongping Liu et al Bioorg. Med. Chem. Lett. 21, 6833-7, (2011)

Inhibitory effect of novel 5-O-acyl juglones on mammalian DNA polymerase activity, cancer cell growth and inflammatory response. Maruo S, Kuriyama I, et al Bioorg. Med. Chem. 19, 5803-5812, (2011)

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Merck 14,5505

Beil. 2,IV,1754

Aldrich MSDS 1, 1138:B / Corp MSDS 1 (1), 2128:C / FT-IR 1 (1), 501:C / FT-IR 2 (1), 786:A / FT-NMR 1 (1), 785:B / Fenaroli (608) / NMR-Reference 2 (1), 437:C / RegBook 1 (1), 551:G / Sax 6, 1707 / Sigma FT-IR 1 (1), 1413:D / Structure Index 1, 78:B:4

类型BSZH 有机化学试剂
安全信息
个人防护装备 Eyeshields, Gloves
WGK德国 1
RTECS RF9990000
燃点(华氏) >235.4 °F
燃点(摄氏) >113 °C