» 产品价格(Market Price)⇒ 联系客服 +
中文名称英文名称CAS 编号规格目录价所属品牌订货号
氯化乙酰胆碱Acetylcholine chloride60-31-125G531.00SIGMAA6625
氯化乙酰胆碱Acetylcholine chloride60-31-1100G1,780.00SIGMAA6625
氯化乙酰胆碱Acetylcholine chloride60-31-1500G5,075.00SIGMAA6625
品牌SIGMA
产品名称 氯化乙酰胆碱 : Acetylcholine chloride ——【产品编号:SIGMA-A6625】
CAS编号60-31-1
别名ACh,乙酰氯化胆碱,2-(乙酰氧基)-N,N,N-三甲基乙铵氯化物
级别科学级
纯度&分析≥99% (TLC)
Tips一种内在的神经递质。
分子式(CH3)3N+CH2CH2OCOCH3Cl-
分子量181.66
储存条件常温避光保存。
性质
assay   ≥99% (TLC)
mp   146-150 °C(lit.)
solubility   H2O: soluble100 mg/mL
APPEARANCE WHITE TO WHITE WITH A FAINT YELLOW CAST POWDER
SOLUBILITY CLEAR COLORLESS SOLUTION AT 400 MG PLUS 4 ML WATER
IR SPECTRUM CONSISTENT WITH STRUCTURE
PURITY BY THIN LAYER CHROMATOGRAPHY NOT LESS THAN 99%
原产地美国
描述

Caution

Very hygroscopic.

Biochem/physiol Actions

Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis 1. The cholinergicanti-infl ammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

供货状态True
参考文献

Palchetti, I., et al., Electrochemical Biosensor Technology: Application To Pesticide Detection. Methods Mol. Biol. 504, 115-26, (2009)

Falcao, S., et al., Impact Of Diet And Stress On The Development Of Preeclampsia-like Symptoms In P57kip2 Mice. Am. J. Physiol. Heart Circ. Physiol. 296, H119-26, (2009)

Sekiguchi-Tonosaki, M., et al., Acetylcholine Induces Ca2+ Signaling In Chicken Retinal Pigmented Epithelial Cells During Dedifferentiation. Am. J. Physiol. Cell Physiol. 296, C1195-206, (2009)

Siemieniuch, M.J., et al., Effects Of Tumor Necrosis Factor-alpha And Nitric Oxide On Prostaglandins Secretion By The Bovine Oviduct Differ In The Isthmus And Ampulla And Depend On The Phase Of The Estrous Cycle. Exp. Biol. Med. 234, 1056-66, (2009)

Wessler, I., et al., The cholinergic 'pitfall': acetylcholine, a universal cell molecule in biological systems, including humans. Clin. Exp. Pharmacol. Physiol. 26, 198-205, (1999)

Perry, E., et al., Acetylcholine in mind: a neurotransmitter correlate of consciousness?. Trends Neurosci. 22, 273-280, (1999)

Israel, M., and Dunant, Y., Acetylcholine release and the cholinergic genomic locus. Mol. Neurobiol. 16, 1-20, (1998)

Pepeu, G., and Blandina, P., The acetylcholine, GABA, glutamate triangle in the rat forebrain. J. Physiol. (Paris) 92, 351-355, (1998)

Merck 14,87

Beil. 4,IV,1446

Aldrich MSDS 1, 19:B / Corp MSDS 1 (1), 35:D / FT-IR 1 (1), 678:C / FT-IR 2 (1), 1130:A / FT-NMR 1 (1), 1078:A / IR-Spectra (2), 350:H / IR-Spectra (3), 396:E / RegBook 1 (1), 773:H / Sax 6, 96 / Sigma FT-IR 1 (2), 1:C / Structure Index 1, 120:B:7

类型BSZH 生物化学研究
安全信息
符号  GHS07
信号词  Warning
危险声明  H315-H319-H335
警示性声明  P261-P305 + P351 + P338
个人防护装备  dust mask type N95 (US), Eyeshields, Gloves
危害码  Xi
风险声明  36/37/38
安全声明  26
WGK德国  2
RTECS  FZ9800000