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中文名称英文名称CAS 编号规格目录价所属品牌订货号
鱼藤酮Rotenone83-79-41G¥370.00SIGMAR8875
鱼藤酮Rotenone83-79-45G¥1,600.00SIGMAR8875
鱼藤酮Rotenone83-79-410G¥2,800.00SIGMAR8875
鱼藤酮Rotenone83-79-425G¥4,600.00SIGMAR8875
鱼藤酮Rotenone83-79-4100G¥12,300.00SIGMAR8875
鱼藤酮Rotenone83-79-41KG¥60,400.00SIGMAR8875
品牌SIGMA
产品名称 鱼藤酮 : Rotenone ——【产品编号:SIGMA-R8875】
CAS编号83-79-4
别名鱼滕酮,鱼滕精,鱼藤精,毒鱼藤素,毒鱼滕素,nicouline,tubatoxin,Nekoe,rotenoid
级别科学级
纯度&分析≥95%,HPLC
Tips此产品纯度较高,可用于生化分析、农药研究、培养或其他科研领域。
分子式C23H22O6
分子量394.42
储存条件常温避光保存。
性质
assay ≥95%
bp 210-220 °C/0.5 mmHg(lit.)
mp 159-164 °C(lit.)
原产地美国
描述

Biochem/physiol Actions

Inhibitor of mitochondrial electron transport at NADH:ubiquinone oxidoreductase. It is readily absorbed through the exoskeletons of arthropods, but poorly absorbed cutaneously or from the gastrointestinal tract of mammals. Rotenone is used to induce a Parkinson-like syndrome as an experimental model in rats.

Inhibitor of mitochondrial electron transport. Neurotoxic agent that can produce a Parkinson-like condition as an animal model for study of etiology and interventions.

供货状态True
参考文献

Fukami, J.I., et al. Science 155, 713, (1967)

Kuznetsov, A.V., et al., Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells. Nat. Protoc. 3, 965-76, (2008)

Verma, R., and Nehru, B., Effect of centrophenoxine against rotenone-induced oxidative stress in an animal model of Parkinson's disease. Neurochem. Int. 55, 369-75, (2009)

Qian, W., and Van Houten, B., Alterations in bioenergetics due to changes in mitochondrial DNA copy number. Methods , (2010)

Shaham, O., et al., A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells Proc. Natl. Acad. Sci. U. S. A. 107, 1571-5, (2010)

Rey, B., et al., Up-regulation of avian uncoupling protein in cold-acclimated and hyperthyroid ducklings prevents reactive oxygen species production by skeletal muscle mitochondria. BMC Physiol. 10, 5, (2010)

Serviddio, G., and Sastre, J., Measurement Of Mitochondrial Membrane Potential And Proton Leak. Methods Mol. Biol. 594, 107-21, (2010)

Qian, W., and Van Houten, B., Alterations In Bioenergetics Due To Changes In Mitochondrial DNA Copy Number. Methods 51, 452-7, (2010)

Caboni, P., et al., Rotenone, deguelin, their metabolites, and the rat model of Parkinson's disease Chem. Res. Toxicol. 17, 1540-1548, (2004)

Uversky, V.N., Neurotoxicant-induced animal models of Parkinson's disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration Cell Tissue Res. 318, 225-241, (2004)

Merck 14,8271

Beil. 19,II,438

Aldrich MSDS 1, 1592:A / Corp MSDS 1 (2), 3055:C / FT-IR 1 (2), 99:A / FT-NMR 1 (2), 923:A / IR-Spectra (3), 907:G / IR-Spectra (2), 794:D / NMR-Reference 2 (2), 99:C / RegBook 1 (2), 1701:B / Sax 6, 2373 / Sigma FT-IR 1 (2), 884:B / Structure Index 1, 270:D:6

类型BSZH 有机化学试剂
安全信息
符号 GHS06GHS09
信号词 Danger
危险声明 H301-H315-H319-H335-H410
警示性声明 P261-P273-P301 + P310-P305 + P351 + P338-P501
危害码 T,N
风险声明 25-36/37/38-50/53
安全声明 22-24/25-36-45-60-61
RIDADR UN 2811 6.1/PG 3
WGK德国 3