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中文名称英文名称CAS 编号规格目录价所属品牌订货号
叶酸Folic acid59-30-35G¥192.00SIGMAF7876
叶酸Folic acid59-30-325G¥760.00SIGMAF7876
叶酸Folic acid59-30-3100G¥2,300.00SIGMAF7876
叶酸Folic acid59-30-3500G¥8,510.00SIGMAF7876
叶酸Folic acid59-30-35KG¥49,000.00SIGMAF7876
品牌SIGMA
产品名称 叶酸 : Folic acid ——【产品编号:SIGMA-F7876】
CAS编号59-30-3
别名N-4-[(2-氨基-4-氧代-1,4-二氢-6-喋啶)甲氨基苯甲酰基]-L-谷氨酸,PteGlu,维生素 M
级别科学级
纯度&分析≥97%
Tips广泛分布的一种B族维生素,有促进骨髓中幼细胞成熟的作用。
分子式 C19H19N7O6
分子量441.40
储存条件常温避光保存。
性质
Appearance (Color) Yellow to Orange
Appearance (Form) Powder
Solubility (Color) Yellow to Orange
Solubility (Turbidity) Clear to Very Slightly Hazy
  50 mg/ml, 1 M NaOH
Water (by Karl Fischer) ≤8.5 %
Carbon (anhydrous) 50.4 - 53.0 %
Nitrogen (anhydrous) 21.6 - 22.8 %
Purity (HPLC) ≥97 %
原产地美国
描述

Biochem/physiol Actions

Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon’ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics).

供货状态True
参考文献

Wang, X., et al., Folate deficiency induces aneuploidy in human lymphocytes in vitro-evidence using cytokinesis-blocked cells and probes specific for chromosomes 17 and 21. Mutat. Res. 551, 167-80, (2004)

Szczypka, M.S., et al., Rare incorporation of bone marrow-derived cells into kidney after folic acid-induced injury. Stem Cells 23, 44-54, (2005)

Vedadi, M., et al., Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination Proc. Natl. Acad. Sci. U. S. A. 103, 15835-40, (2006)

Lindberg, H.K., et al., Origin of nuclear buds and micronuclei in normal and folate-deprived human lymphocytes. Mutat. Res. 617, 33-45, (2007)

Froquet, R., et al., Dictyostelium discoideum: a model host to measure bacterial virulence. Nat. Protoc. 4, 25-30, (2009)

Nzila A., Inhibitors of de novo folate enzymes in Plasmodium falciparum. Drug Discov. Today 11, 939-944, (2006)

Gangjee A, Kurup S, Namjoshi O., Dihydrofolate reductase as a target for chemotherapy in parasites. Curr. Pharm. Des. 13, 609-639, (2007)

Abali EE, Skacel NE, Celikkaya H, Hsieh YC., Regulation of human dihydrofolate reductase activity and expression. Vitam. Horm. 79, 267-292, (2008)

Merck 14,4221

Beil. 26,IV,3944

类型维生素
安全信息
个人防护装备  Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK德国  1
RTECS  LP5425000