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中文名称英文名称CAS 编号规格目录价所属品牌订货号
3-异丁基-1-甲基黄嘌呤3-Isobutyl-1-methylxanthine28822-58-4100MG480.00SIGMAI7018
3-异丁基-1-甲基黄嘌呤3-Isobutyl-1-methylxanthine28822-58-4250MG1,494.00SIGMAI7018
3-异丁基-1-甲基黄嘌呤3-Isobutyl-1-methylxanthine28822-58-41G4,527.00SIGMAI7018
3-异丁基-1-甲基黄嘌呤3-Isobutyl-1-methylxanthine28822-58-45G21,270.00SIGMAI7018
品牌SIGMA
产品名称 3-异丁基-1-甲基黄嘌呤 : 3-Isobutyl-1-methylxanthine ——【产品编号:SIGMA-I7018】
CAS编号28822-58-4
别名IBMX,MIX,1-甲基-3-异丁基黄嘌呤,3,7-二氢-1-甲基-3-(2-甲基丙基)-1H-嘌呤-2,6-二酮,3-异丁基-1-甲基-2,6(1H,3H)-嘌呤二酮,1-Methyl-3-isobutylxanthine,3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione,3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione
级别生化级
纯度&分析BioUltra, ≥99%
TipsNon-specific inhibitor of cAMP and cGMP phosphodiesterases.
分子式 C10H14N4O2
分子量222.24
储存条件-20 °C 低温冷冻保存。
性质
product line BioUltra
assay ≥99%
total impurities <0.005% Phosphorus (P)
ign. residue <0.1%
mp 200-201 °C(lit.)
anion traces sulfate (SO42-): <0.05%
cation traces Al: <0.0005%
  Ca: <0.005%
  Cu: <0.0005%
  Fe: <0.005%
  K: <0.05%
  Mg: <0.005%
  NH4+: <0.05%
  Na: <0.005%
  Pb: <0.001%
  Zn: <0.0005%
storage temp. −20°C
原产地美国
描述

Biochem/physiol Actions

Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons.1

供货状态True
参考文献

1. Usachev, Y., and Verkhratsky, A., IBMX induces calcium release from intracellular stores in rat sensory neurones Cell Calcium 17, 197-206, (1995)

Tengholm, A., et al., Single Cell Imaging of PI3K Activity and Glucose Transporter Insertion Into the Plasma Membrane by Dual Color Evanescent Wave Microscopy Science Signaling 2003, (2003)

Carter, P.H., et al., Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe Proc. Natl. Acad. Sci. U. S. A. 104, 6846-51, (2007)

Villeneuve, D.L., et al., Effects of a 3{beta}-Hydroxysteroid Dehydrogenase Inhibitor, Trilostane, on the Fathead Minnow Reproductive Axis Toxicol. Sci. 104, 113-23, (2008)

Park, K.W., et al., Inhibitor of DNA Binding 2 Is a Small Molecule-Inducible Modulator of Peroxisome Proliferator-Activated Receptor-{gamma} Expression and Adipocyte Differentiation Mol. Endocrinol. 22, 2038-48, (2008)

Xu, J., et al., Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects Am. J. Physiol. Endocrinol. Metab. 297, 1105, (2009)

Xu, J., et al., Acute Glucose-lowering And Insulin-sensitizing Action Of FGF21 In Insulin-resistant Mouse Models—association With Liver And Adipose Tissue Effects Am. J. Physiol. Endocrinol. Metab. 297, E1105-E1114, (2009)

Villeneuve, D.L., et al., Direct Effects, Compensation, And Recovery In Female Fathead Minnows Exposed To A Model Aromatase Inhibitor. Environ. Health Perspect. 117, 624-31, (2009)

Park, K.W., et al., The Small Molecule Phenamil Is A Modulator Of Adipocyte Differentiation And PPARgamma Expression. J. Lipid Res. 51, 2775-84, (2010)

Scheller, E.L., et al., Leptin Functions Peripherally To Regulate Differentiation Of Mesenchymal Progenitor Cells. Stem Cells 28, 1071-80, (2010)

Chen, M.C., et al., Involvement Of CAMP In Nerve Growth Factor-triggered P35/Cdk5 Activation And Differentiation In PC12 Cells. Am. J. Physiol. Cell Physiol. 299, C516-27, (2010)

Garavaglia, A., et al., Adaptation Of NS Cells Growth And Differentiation To High-throughput Screening-compatible Plates. BMC Neurosci. 11, 7, (2010)

Shafer, S.H., et al., Reduced DNA synthesis and cell viability in small cell lung carcinoma by treatment with cyclic AMP phosphodiesterase inhibitors. Biochem. Pharmacol. 56, 1229-1236, (1998)

Chen, T.C., et al., Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas. Lab. Invest. 78, 165-174, (1998)

Elks, M.L., and Manganiello, V.C., A role for soluble cAMP phosphodiesterases in differentiation of 3T3-L1adipocytes. J. Cell Physiol. 124, 191-198, (1985)

Freitag, A., et al., Phosphodiesterase inhibitors suppress α2-adrenoceptor-mediated 5-hydroxytryptamine release from tracheae of newborn rabbits. Eur. J. Pharmacol. 354, 67-71, (1998)

McKinley, J.B., et al., The interaction of adenosine analogues with cAMP-generating and cAMP-independent positive inotropic agents in rabbit left atrium. Naunyn Schmiedebergs Arch. Pharmacol. 342, 605-612, (1990)

Fearon, I.M., et al., Inhibition of recombinant human cardiac L-type Ca2+ channel α1C subunits by 3-isobutyl-1-methylxanthine. Eur. J. Pharmacol. 342, 353-358, (1998)

Beil. 26,IV,2350

FT-IR 1 (2), 711:C / FT-IR 2 (3), 3670:A / IR-Spectra (2), 1120:G / IR-Spectra (3), 1288:B / NMR-Reference 2 (2), 586:D / RegBook 1 (2), 2467:K / Sigma FT-IR 1 (1), 1002:C / Structure Index 1, 390:E:4

类型BSZH 生物化学研究
安全信息
符号 GHS07
信号词 Warning
危险声明 H302
个人防护装备 dust mask type N95 (US), Eyeshields, Faceshields, Gloves
危害码 Xn
风险声明 22
WGK德国 3
RTECS ZD8500000