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中文名称英文名称CAS 编号规格目录价所属品牌订货号
曲古霉素 ATrichostatin A58880-19-65MG6,300.00SIGMAT8552
曲古霉素 ATrichostatin A58880-19-610MG9,720.00SIGMAT8552
曲古霉素 ATrichostatin A58880-19-6100MG75,300.00SIGMAT8552
品牌SIGMA
产品名称 曲古霉素 A : Trichostatin A ——【产品编号:SIGMA-T8552】
CAS编号58880-19-6
别名曲古霉素A,TrichostatinA,曲古抑菌素A,曲古菌素A,曲古柳菌素A,TSA,[R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
级别科学级
纯度&分析≥98% (HPLC), from Streptomyces sp.
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分子式C17H22N2O3
分子量302.37
储存条件-20 °C 低温冷冻保存。
性质
biological source   from Streptomyces sp.
assay   ≥98% (HPLC)
solubility   methanol: soluble1.90 - 2.10 mg/mL, clear, colorless to faint yellow or tan
  DMF: soluble
  DMSO: soluble
  H2O: insoluble
  acetone: slightly soluble
  acetonitrile: soluble
  benzene: slightly soluble
  chloroform: slightly soluble
  ethanol: soluble
  ethyl acetate: slightly soluble
  lower alcohols: soluble
storage temp.   −20°C
原产地美国
描述
Preparation Note

Trichostatin A is soluble in methanol at 1.90 - 2.10 mg/ml and yields a clear, colorless to faint yellow/tan solution. It is also soluble in DMSO, DMF, acetonitrile, ethanol and lower alcohols. Trichostatin A is sparingly soluble in chloroform, ethyl acetate, acetone, and benzene. However, it is insoluble in water.

Application

Trichostatin A (TSA) has been used during the production of cloned mouse embryos1. TSA has also been used as a histone deacetylase (HDAC) inhibitor in LNCaP human prostate cancer cells2, as well as in MON and HeLa cells3.

Biochem/physiol Actions

Inhibits histone deacetylase at nanomolar concentrations; resultant histone hyperacetylation leads to chromatin relaxation and modulation of gene expression. May be involved in cell cycle progression of several cell types, inducing cell growth arrest at both G and G/M phases; may induce apoptosis. Enhances the efficacy of anticancer agents that target DNA.

供货状态True
参考文献

Satoshi Kishigami and Teruhiko Wakayama
Journal of Reproduction and Development, 53(6), 1207-1215 (2007
Somdutta Roy and Martin Tenniswood
Journal of Biological Chemistry, 282(7), 4765-4771 (2007)

类型抗生素
安全信息
符号  GHS07  
信号词  Warning
危险声明  H302-H312-H315-H317-H319-H332-H335
警示性声明  P261-P280-P305 + P351 + P338
个人防护装备  dust mask type N95 (US), Eyeshields, Faceshields, Gloves
危害码 (欧洲)  Xn
风险声明 (欧洲)  20/21/22-36/37/38-43
安全声明 (欧洲)  26-36
WGK德国  3
RTECS  MI5215000