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中文名称英文名称CAS 编号规格目录价所属品牌订货号
牛血纤维蛋白原Fibrinogen from bovine plasma9001-32-5100MG¥384.00SIGMAF8630
牛血纤维蛋白原Fibrinogen from bovine plasma9001-32-51G¥1,738.00SIGMAF8630
牛血纤维蛋白原Fibrinogen from bovine plasma9001-32-55G¥5,336.00SIGMAF8630
牛血纤维蛋白原Fibrinogen from bovine plasma9001-32-525G¥18,626.00SIGMAF8630
牛血纤维蛋白原Fibrinogen from bovine plasma9001-32-5100G¥65,560.00SIGMAF8630
牛血纤维蛋白原Fibrinogen from bovine plasma9001-32-51KG¥479,800.00SIGMAF8630
品牌SIGMA
产品名称 牛血纤维蛋白原 : Fibrinogen from bovine plasma ——【产品编号:SIGMA-F8630】
CAS编号9001-32-5
别名牛纤维蛋白原,Fibrinogen bovine,bovine Fibrinogen,Factor I
级别科学级
纯度&分析Type I-S, 65-85% protein (≥75% of protein is clottable)
Tips此产品来源于牛血浆,可用于生化分析、细胞培养或其他科研领域。
分子式N/A
分子量N/A
储存条件-20 °C 低温冷冻保存。
性质
type Type I-S
mol wt α-chain mol wt 63.5 kDa
  β-chain mol wt 56 kDa
  γ chain mol wt 47 kDa (about 4% carbohydrate content)
  soluble dimer mol wt 340 kDa
storage temp. −20°C
原产地美国
描述

Analysis Note

Protein determined by biuret

Physical form

Contains ~10% sodium citrate and ~15% sodium chloride.

Biochem/physiol Actions

Fibrinogen is an acute phase protein that is part of the coagulation cascade of proteins. The end result of the cascade is the production of thrombin that converts fibrinogen to fibrin. Thrombin rapidly proteolyzes fibrinogen, releasing fibrinopeptide A. The loss of this small peptide is not sufficient to make the resulting fibrin molecule insoluble, but it tends to form complexes with adjacent fibrin and fibrinogen molecules. Thrombin then cleaves a second peptide, fibrinopeptide B, from fibrin and the fibrin monomers formed then polymerize spontaneously to form an insoluble gel. The polymerized fibrin is held together by noncovalent and electrostatic forces and stabilized by the transamidating enzyme, factor XIIIa, that is produced by the action of thrombin on factor XIII. The insoluble fibrin aggregates (clots) and aggregated platelets then block the damaged blood vessel and prevent further bleeding. The amount of fibrinogen in the plasma can serve as a nonspecific indicator of whether or not an inflammatory process is present in the body. Fibrinogen from any mammalian source will be cleaved by thrombin from any mammalian source.

供货状态True
参考文献

Rinaudo, M., Rheological investigation on hyaluronan-fibrinogen interaction. Int. J. Biol. Macromol. 43, 444-50, (2008)

Choi, N.S., et al., Mixed-substrate (glycerol tributyrate and fibrin) zymography for simultaneous detection of lipolytic and proteolytic enzymes on a single gel. Electrophoresis 30, 2234-7, (2009)

Choi, N.S., et al., Multiple-layer substrate zymography for detection of several enzymes in a single sodium dodecyl sulfate gel. Anal. Biochem. 386, 121-2, (2009)

Andrades, M.E., et al., Glycolaldehyde induces fibrinogen post-translational modification, delay in clotting and resistance to enzymatic digestion. Chem. Biol. Interact. 180, 478-84, (2009)

Merck 14,4071

类型蛋白质
安全信息
个人防护装备 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK德国 3