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中文名称英文名称CAS 编号规格目录价所属品牌订货号
渥曼青霉素Wortmannin19545-26-71MG¥730.00SIGMAW1628
渥曼青霉素Wortmannin19545-26-75MG¥2,755.00SIGMAW1628
渥曼青霉素Wortmannin19545-26-710MG¥4,800.00SIGMAW1628
品牌SIGMA
产品名称 渥曼青霉素 : Wortmannin ——【产品编号:SIGMA-W1628】
CAS编号19545-26-7
别名KY 12420,沃氏篮酶素,奥特曼宁,antibioticsl-2052,sl-2052
级别科学级
纯度&分析from Penicillium funiculosum, ≥98% (HPLC and TLC)
TipsBSZH品质推荐:SIGMA-ALDRICH 进口高等级试剂,多重遴选,国际标准严苛测试,全球生物化学产品质量标杆,满足用户更高应用要求。 使用SIGMA-ALDRICH品质优异、表现卓越的试剂类产品,将有助于使您的研究项目更早获益。
分子式C23H24O8
分子量428.43
储存条件2-8 °C 冷藏保存。
性质

用途及描述:

生化试剂,生化实验研究,渥曼青霉素(Wortmannin)是有效的特异性的磷脂酰肌醇3-激酶(PI3-K)抑制剂,IC50为2-4 nM。可抑制自噬体的形成,也有效抑制DNA-PK/ATM,IC50分别为16 nM 和 150 nM。
Wortmannin通过对PI3-K/Akt信号传导途径的抑制,能够提高辐射或者去血清培养诱导的细胞凋亡效果,也能阻止细胞因子的抗细胞凋亡作用。渥曼青霉素对PI3-K的抑制作用也可以阻止由胰岛素受体活化引起的许多短期代谢效应。Wortmannin无明显的抗细菌作用,但具有很强的抑制真菌活性;
Wortmannin与LY294002 都是PI3K的常用抑制剂;LY294002是第一个人工合成的抑制PI3Kα/δ/β的分子,IC50分别为0.5 μM、0.57 μM、0.97 μM,在溶液中比Wortmannin稳定,也抑制自噬体的形成。Wortmannin与对比,LY294002会引起细胞内钙离子浓度的变化,而wortmannin通常不会,因此,它与wortmannin相比,会对细胞其他活性造成不同的影响。如果研究与细胞内钙离子浓度密切相关,那么应用LY294002时就要更加谨慎(仅供参考)。

~Quality Level   PREMIUM
biological source   from Penicillium funiculosum
InChI Key   QDLHCMPXEPAAMD-QAIWCSMKSA-N
assay   ≥98% (HPLC and TLC)
form   powder
color   off-white
solubility   DMSO: soluble
  H2O: unstable
storage temp.   2-8°C

原产地美国
描述

Biochem/physiol Actions
Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor with an IC50 of 2-4 nM. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Inhibition of PI3-K by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation.


Features and Benefits
This compound is a featured product for Cyclic Nucleotide and Kinase Phosphatase Biology research. Discover more featured Cyclic Nucleotide and Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
This compound is featured on the G Proteins (Heterotrimeric) and Phosphoinositide Kinases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.


法律信息
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

供货状态True
参考文献N/A
类型抗生素
安全信息

符号  GHS06  GHS06
信号词  Danger
危害声明  H300-H310-H330
警示性声明  P260-P264-P280-P284-P302 + P350-P310
个人防护装备  Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
危害码 (欧洲)  T+
风险声明 (欧洲)  26/27/28
安全声明 (欧洲)  28-36/37-45
RIDADR  UN 3462 6.1 / PGI
WGK德国  3
RTECS  CB9641000