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中文名称英文名称CAS 编号规格目录价所属品牌订货号
阿霉素盐酸盐Doxorubicin hydrochloride25316-40-910MG2,316.00SIGMAD1515
阿霉素盐酸盐Doxorubicin hydrochloride25316-40-925MG2,950.00SIGMAD1515
阿霉素盐酸盐Doxorubicin hydrochloride25316-40-9100MG5,850.00SIGMAD1515
阿霉素盐酸盐Doxorubicin hydrochloride25316-40-9500MG18,430.00SIGMAD1515
品牌SIGMA
产品名称 阿霉素盐酸盐 : Doxorubicin hydrochloride ——【产品编号:SIGMA-D1515】
CAS编号25316-40-9
别名阿霉素 盐酸盐,盐酸阿霉素,DOX,多柔比星盐酸盐,羟基柔红霉素盐酸盐,Hydroxydaunorubicin hydrochloride
级别科学级
纯度&分析98.0-102.0% (HPLC)
Tips本品可用于科研、辅料、规模化生产等。
分子式 C27H29NO11 · HCl
分子量579.98
储存条件2-8 °C 冷藏保存。
性质
Related Categories Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics,Antitumor Agents, Apoptosis and Cell Cycle, Bioactive Small Molecules, Biochemicals and Reagents, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Chemical Structure Class, Core Bioreagents, DIG-DY, DNA-RNA Transcription Regulators, Detection and Quantitation, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Fluorescent Labels, Fluorescent Probes, Labels, Particles and Stains, Interferes with DNA Synthesis, Mechanism of Action, Multi-Drug Resistance, Multi-Drug Resistance and Drug Metabolism, Other Apoptosis Related Reagents, Other Fluorescent Labels, R to Z, Reagents, Research Essentials, Reverse Transcriptase, AMV, Tetracyclines
assay   98.0-102.0% (HPLC)
mp   216 °C (dec.)(lit.)
storage temp.   2-8°C
原产地美国
描述

Biochem/physiol Actions

Antitumour antibiotic. Effect of adriamycin® on heart mitochondrial DNA;1 Properties.2,3

Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent; intercalates in DNA.

Naturally fluorescent anthracycline antibiotic, anticancer drug. Doxorubicin is a substrate of MRP1 which was first cloned from a DOX-resistant lung cancer cell line. Fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (Golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes.

Legal Information

Adriamycin is a registered trademark of RDF Pharmacia & Upjohn S.P.A.

供货状态True
参考文献

1. Effect of adriamycin on heart mitochondrial DNA. C.N. Ellis et al. Biochem. J. 245, 309, (1987)

2. R.J. White et al. Drugs Pharm. Sci. 22, 569, (1984)

3. A. Vigevani, M.J. Williamson Anal. Profiles Drug Subst. 9, 245, (1980)

Separate roles for the Golgi apparatus and lysosomes in the sequestration of drugs in the multidrug-resistant human leukemic cell line HL-60. Gong, Y., et al. J. Biol. Chem. 278, 50234-50239, (2003)

Subcellular localization and activity of multidrug resistance proteins. Rajagopal, A., and Simon, S.M. Mol. Biol. Cell 14, 3389-3399, (2003)

Neutralization Of Interleukin-18 Ameliorates Ischemia/reperfusion-induced Myocardial Injury. Venkatachalam, K., et al. J. Thorac. Cardiovasc. Surg. 284, 7853-65, (2009)

Doxorubicin Enhances CD4(+) T-cell Immune Responses By Inducing Expression Of CD40 Ligand And 4-1BB. Park, J.Y., et al. Int. Immunopharmacol. 9, 1530-9, (2009)

High Levels Of Hsp90 Cochaperone P23 Promote Tumor Progression And Poor Prognosis In Breast Cancer By Increasing Lymph Node Metastases And Drug Resistance. Simpson, N.E., et al. Cancer Res. 70, 8446-56, (2010)

Role Of Progerin-induced Telomere Dysfunction In HGPS Premature Cellular Senescence. Benson, E.K., et al. J. Cell Biol. 123, 2605-12, (2010)

Srg3, A Mouse Homolog Of BAF155, Is A Novel P53 Target And Acts As A Tumor Suppressor By Modulating P21(WAF1/CIP1) Expression. Ahn, J., et al. Oncogene 30, 445-56, (2011)

Poly(ethylene Glycol)-conjugated Multi-walled Carbon Nanotubes As An Efficient Drug Carrier For Overcoming Multidrug Resistance. Cheng, J., et al. Toxicol. Appl. Pharmacol. 250, 184-93, (2011)

Cytotoxic drugs and the CD95 pathway. Friesen, C., et al. Leukemia 13, 1854, (1999)

Histology and sensitivity to anticancer drugs of two human non-small cell lung carcinomas implanted in the pleural cavity of nude mice. Clin. Kraus-Berthier, L, et al. Cancer Res. 6, 297-304, (2000)

Doxorubicin/taxane combinations: cardiac toxicity and pharmacokinetics. Sparano, J.A. Semin. Oncol. 26, 14-19, (1999)

Merck 14,3439

Aldrich MSDS 1, 849:A / Corp MSDS 1 (1), 1499:A / RegBook 1 (2), 1691:D / Sax 6, 144 / Structure Index 1, 268:B:6

类型抗生素
安全信息
符号  GHS07GHS08
信号词  Danger
危险声明  H302-H350
警示性声明  P201-P308 + P313
个人防护装备  Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
危害码 (欧洲)  T
风险声明 (欧洲)  45-22
安全声明 (欧洲)  53-45
WGK德国  3
RTECS  QI9295900