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中文名称英文名称CAS 编号规格目录价所属品牌订货号
塞来昔布Celecoxib169590-42-55MG852.00SIGMAPZ0008
塞来昔布Celecoxib169590-42-525MG3,625.00SIGMAPZ0008
塞来昔布Celecoxib169590-42-5100MG8,930.00SIGMAPZ0008
塞来昔布Celecoxib169590-42-51G46,530.00SIGMAPZ0008
品牌SIGMA
产品名称 塞来昔布 : Celecoxib ——【产品编号:SIGMA-PZ0008】
CAS编号169590-42-5
别名塞内昔布,噻利考西,4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide,CJ-016377,CP-598107,PF-00345549,PHA-00846533,SC-58635,YM-177
级别科学级
纯度&分析≥98% (HPLC)
Tips一种常用的化学原料药,用于科研、辅料、规模化生产等。
分子式 C17H14F3N3O2S
分子量381.37
储存条件常温避光保存。
性质
assay   ≥98% (HPLC)
form   powder
color   white to off-white
solubility   DMSO: >20 mg/mL
storage temp.   room temp
原产地美国
描述

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

Biochem/physiol Actions

Celecoxib is a non-steroidal, anti-inflammatory drug (NSAID) and a cyclooxygenase-2 (COX-2) selective inhibitor. Celecoxib is at least 10-20 times more selective for COX-2 over COX-1.

供货状态True
参考文献

Arsenic Trioxide Inhibits Invasion/migration In SGC-7901 Cells By Activating The Reactive Oxygen Species-dependent Cyclooxygenase-2/matrix Metalloproteinase-2 Pathway. Liu, Y., et al. Exp. Biol. Med. 236, 592-7, (2011)

Differential effects of selective cyclooxygenase-2 inhibitors on vascular smooth muscle ion channels may account for differences in cardiovascular risk profiles. Brueggemann LI., et al. Mol. Pharmacol. 76, 1053-1061, (2009)

Major role of human liver microsomal cytochrome P450 2C9 (CYP2C9) in the oxidative metabolism of celecoxib, a novel cyclooxygenase-II inhibitor. Tang C., et al. J. Pharmacol. Exp. Ther. 293, 453-459, (2000)

The biochemical selectivity of novel COX-2 inhibitors in whole blood assays of COX-isozyme activity. Tacconelli S., et al. Curr. Med. Res. Opin. 18, 503-511, (2002)

Merck 14,1956

类型BSZH 生物化学研究
安全信息
符号  GHS08
信号词  Danger
危险声明  H360
警示性声明  P201-P308 + P313
危害码 (欧洲)  Xn
风险声明 (欧洲)  60-61-52
安全声明 (欧洲)  22
WGK德国  3
RTECS  DB2944937