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中文名称英文名称CAS 编号规格目录价所属品牌订货号
细胞色素 C(源于牛心脏)Cytochrome c from bovine heart9007-43-625MG¥636.00SIGMAC2037
细胞色素 C(源于牛心脏)Cytochrome c from bovine heart9007-43-6100MG¥1,550.00SIGMAC2037
细胞色素 C(源于牛心脏)Cytochrome c from bovine heart9007-43-65G¥41,207.00SIGMAC2037
品牌SIGMA
产品名称 细胞色素 C(源于牛心脏) : Cytochrome c from bovine heart ——【产品编号:SIGMA-C2037】
CAS编号9007-43-6
别名牛细胞色素C
级别科学级
纯度&分析≥95% based on Mol. Wt. 12,327 basis
Tips细胞色素 C是一种电子负载线粒体蛋白质,是一​种通用的呼吸作用催化剂,能在呼吸底物和氧之间形成必​要的电子桥。
分子式N/A
分子量N/A
储存条件-20 °C 低温冷冻保存。
性质
assay ≥95% based on Mol. Wt. 12,327 basis
mol wt mol wt 12327 Da
storage temp. −20°C
Gene Information cow ... CYC1(512500)
原产地美国
描述

Preparation Note

Prepared using TCA.

Application

Cytochrome c has been identified as an important mediator in apoptotic pathways. The release of mitochondrial cytochrome c into the cytoplasm stimulates apoptosis and is commonly used as an indicator of the apoptotic process in the cell. Investigation on the effect of Paris Saponin I (PS I) on human gastric carcinoma cell growth (SGC7901 cells) have shown an elevated level cytoplasmic cytochrome c. Results are an inhibition of proliferation in SGC7901 cells by inducing mitochondria-dependent apoptosis through cytochrome c.

Biochem/physiol Actions

The ready interconversion of cytochrome c between ferrous and ferric states makes it an efficient biological electron carrier. It plays a vital role in cellular oxidations in both plants and animals. Generally regarded as a universal link in the respiratory chain, it forms the essential electron-bridge between the respirable substrates and oxygen.

供货状态True
参考文献

An integrated top-down and bottom-up strategy for broadly characterizing protein isoforms and modifications. Wu, S., et al. J. Proteome Res. 8, 1347-57, (2009)

Discrimination Analysis Of Human Lung Cancer Cells Associated With Histological Type And Malignancy Using Raman Spectroscopy. Oshima, Y., et al. J. Biomed. Opt. 15, 17009, (2010)

Paris chinensis dioscin induces G2/M cell cycle arrest and apoptosis in human gastric cancer SGC-7901 cells. Gao L., et al. World J. Gastroenterol. 17, 4389-4395, (2011)

Opening the doors to cytochrome c: changes in mitochondrial shape and apoptosis Scoranno, L. Int. J. Biochem. Cell Biol. 41, 1875-1883, (2009)

Regulation of apoptosis by the redox state of cytochrome c Brown, G,C,, and Borutaite, V. Biochim. Biophys. Acta 177, 877-881, (2008)

Merck 14,2791

类型生物化学
安全信息
个人防护装备 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK德国 3
RTECS HA5365000