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中文名称英文名称CAS 编号规格目录价所属品牌订货号
罗红霉素Roxithromycin80214-83-11G¥290.00SIGMAR4393
罗红霉素Roxithromycin80214-83-15G¥762.00SIGMAR4393
罗红霉素Roxithromycin80214-83-110G¥1,325.00SIGMAR4393
品牌SIGMA
产品名称 罗红霉素 : Roxithromycin ——【产品编号:SIGMA-R4393】
CAS编号80214-83-1
别名roxyithromycin;biaxsig;Brilid;Makrodex;Romycin;Roxithromycinum;Rulid;Rulide;Ru-28965;Surlid
级别科学级
纯度&分析≥90% (HPLC)
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分子式C41H76N2O15
分子量837.05
储存条件2-8 °C 冷藏保存。
性质

用途及描述:

科研试剂,广泛应用于分子生物学,药理学等科研方面。本品为半合成的14元环大环内酯类抗生素。抗菌谱与抗菌作用基本上与红霉素相仿,对革兰阳性菌的作用较红霉素略差,对嗜肺军团菌的作用较红霉素强。对肺炎衣原体、肺炎支原体、溶脲脲原体的抗微生物作用与红霉素相仿或略强。

本品可透过细菌细胞膜,在接近供体(“P”位)与细菌核糖体的50S亚基成可逆性结合,阻断了转移核糖核酸(t-RNA)结合至“P”位上,同时也阻断了多肽链自受位(“A”位)至“P”位的转移,因而细菌蛋白质合成受到抑制。
储存条件:室温,避光防潮密闭干燥。
溶解性:在乙醇或丙酮中易溶,在甲醇中溶解,在乙腈中略溶,在水中几乎不溶。

assay   ≥90% (HPLC)
form   powder
solubility   chloroform: soluble10 mg/mL
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   2-8°C

原产地美国
描述

Biochem/physiol Actions
Semisynthetic erythromycin derivative. Impairs NADPH oxidase activation and alters translocation of its cytosolic components to the neutrophil membrane.
Roxithromycin impairs NADPH oxidase activation and alters translocation of its cytosolic components to the neutrophil membrane. It is similar in composition, chemical structure and mechanism of action to erythromycin, azithromycin, and clarithromycin. Roxithromycin binds to the subunit 50S of the bacterial ribosome, inhibiting the translocation of peptides[1].

Application
Roxithromycin is a semi-synthetic macrolide antibiotic. Roxithromycin is used to block bacterial protein synthesis. Clinically, it is used to treat respiratory tract, urinary and soft tissue infections. It has a similar antimicrobial spectrum as erythromycin, but is the preferred treatment for certain gram-negative bacteria, such as Legionella pneumophila[1].


Other Notes
Keep container tightly closed in a dry and well-ventilated place.

供货状态True
参考文献N/A
类型抗生素
安全信息

符号  GHS07  GHS07
信号词  Warning
危害声明  H302
个人防护装备  dust mask type N95 (US), Eyeshields, Gloves
危害码 (欧洲)  Xn
风险声明 (欧洲)  22
RIDADR  NONH for all modes of transport
WGK德国  3
RTECS  KF4990000