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中文名称英文名称CAS 编号规格目录价所属品牌订货号
多粘菌素E硫酸盐Colistin sulfate salt1264-72-8100MG430.00SIGMAC4461
多粘菌素E硫酸盐Colistin sulfate salt1264-72-81G1,900.00SIGMAC4461
多粘菌素E硫酸盐Colistin sulfate salt1264-72-85G5,200.00SIGMAC4461
品牌SIGMA
产品名称 多粘菌素E硫酸盐 : Colistin sulfate salt ——【产品编号:SIGMA-C4461】
CAS编号1264-72-8
别名硫酸粘杆菌素,Polymyxin E,硫酸多粘菌素E
级别科学级
纯度&分析≥15,000 U/mg
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分子式C53H100O13N16
分子量2801.27
储存条件2-8 °C 冷藏保存。
性质

属抗生素类药,本品仅供科研,本品由多粘杆菌产生,对革兰氏阴性菌有较强的抗菌作用,用于治疗革兰氏阴性菌引起的肠道疾病。硫酸粘杆菌素用于,穿透细菌的

性状:白色至类白色或微黄色粉末;无臭或几乎无臭。有引湿性。在水中易溶,在乙醇中微溶,在丙酮、氯仿或乙醚中几乎不溶。

~form   powder
solubility   H2O: soluble50 mg/mL
Mode of action   cell membrane | interferes
antibiotic activity spectrum   Gram-negative bacteria
storage temp.   2-8°C

原产地美国
描述

Biochem/physiol Actions
Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria.
Mode of Action: Binds to lipids on the cell cytoplasmic membrane of Gram-negative bacteria and disrupts the cell wall integrity.
Antimicrobial spectrum: Gram-negative bacteria. It is proposed that renal reabsorption of colistin may involve organic cation transporters and peptide transporters and that the process is sensitive to pH [1].

Application
Colistin sulfate is used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination and antibiotic resistance in certain organisms such as A. baumannii [2]. It has been used to study hephrotoxicity in the rat kidney [1], and MICs, time-kill kinetics, and postantibiotic effect (PAE) against Pseudomonas aeruginosa [3].


Other Notes
Keep container tightly closed in a dry and well-ventilated place.

供货状态True
参考文献N/A
类型抗生素
安全信息

~符号  GHS06  GHS06
信号词  Danger
危害声明  H301
警示性声明  Missing Phrase - N15.00950417
个人防护装备  Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
危害码 (欧洲)  T
风险声明 (欧洲)  25
安全声明 (欧洲)  45
RIDADR  UN 2811 6.1 / PGIII
WGK德国  3
RTECS  TR1500000