品牌 |  |
产品名称 |
头孢拉定 : Cephradine ——【产品编号:SIGMA-C8395】
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CAS编号 | 38821-53-3 |
别名 | 先锋瑞丁、头孢拉丁、头孢握定、头孢雷定、己环胺菌素、头孢环己烯、环己烯胺头孢菌素、环烯头孢菌素,Cefradin |
级别 | 科学级 |
纯度&分析 | powder |
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分子式 | C16H19N3O4S |
分子量 | 349.40 |
储存条件 | 2-8 °C 冷藏保存。 |
性质 | 头孢拉定别名:先锋霉素Ⅵ、头孢菌素Ⅵ等。头孢拉定为第一代半合成头孢菌素,抗菌作用与头孢氨苄相似。头孢拉定对耐药性金葡菌及其它多种对广谱抗生素耐药的杆菌等有迅速而可靠的杀菌作用
厌氧革兰阳性菌对该品多敏感,脆弱拟杆菌对该品呈现耐药。耐甲氧西林葡萄球菌属、肠球菌属对该品耐药。该品对革兰阳性菌与革兰阴性菌的作用与头孢氨苄相似。该品对淋球菌有一定作用,对产酶淋球菌也具活性;对流感嗜血杆菌的活性较差。
该品在水中略溶,在乙醇、氯仿、乙醚中几乎不溶。
InChI Key RDLPVSKMFDYCOR-UEKVPHQBSA-N
form powder
solubility 1 M NH4OH: soluble50 mg/mL
Mode of action cell wall synthesis | interferes
antibiotic activity spectrum Gram-negative bacteria
Gram-positive bacteria
storage temp. 2-8°C
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原产地 | 美国 |
描述 | ~Application
Cefradin was used to study the effect of expression, binding, and inhibition of PBP3 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis.
Biochem/physiol Actions
Cefradin is a semi-synthetic cephalosporin that inhibits the last stage of bacterial cell wall synthesis by binding to certain penicillin-binding proteins (PBPs), such as PBP3, which results in cell lysis. Cell lysis is mediated by bacterial cell wall autolytic enzymes. It is effective against Gram-positive and Gram-negative bacteria. Cefradin may also interfere with autolysin inhibitors.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
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供货状态 | True |
参考文献 | N/A |
类型 | 抗生素 |
安全信息 | 符号 GHS07GHS08 GHS07, GHS08
信号词 Danger
危害声明 H315-H317-H319-H334-H335
警示性声明 P261-P280-P305 + P351 + P338-P342 + P311
危害码 (欧洲) Xn
风险声明 (欧洲) 36/37/38-42/43
安全声明 (欧洲) 22-26-36/37-45
RIDADR NONH for all modes of transport
WGK德国 2
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