头孢拉定别名:先锋霉素Ⅵ、头孢菌素Ⅵ等。头孢拉定为第一代半合成头孢菌素，抗菌作用与头孢氨苄相似。头孢拉定对耐药性金葡菌及其它多种对广谱抗生素耐药的杆菌等有迅速而可靠的杀菌作用
 厌氧革兰阳性菌对该品多敏感，脆弱拟杆菌对该品呈现耐药。耐甲氧西林葡萄球菌属、肠球菌属对该品耐药。该品对革兰阳性菌与革兰阴性菌的作用与头孢氨苄相似。该品对淋球菌有一定作用，对产酶淋球菌也具活性;对流感嗜血杆菌的活性较差。
 该品在水中略溶，在乙醇、氯仿、乙醚中几乎不溶。

InChI Key   RDLPVSKMFDYCOR-UEKVPHQBSA-N
form   powder
solubility   1 M NH4OH: soluble50 mg/mL
Mode of action   cell wall synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   2-8°C

~Application
Cefradin was used to study the effect of expression, binding, and inhibition of PBP3 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis.
Biochem/physiol Actions
Cefradin is a semi-synthetic cephalosporin that inhibits the last stage of bacterial cell wall synthesis by binding to certain penicillin-binding proteins (PBPs), such as PBP3, which results in cell lysis. Cell lysis is mediated by bacterial cell wall autolytic enzymes. It is effective against Gram-positive and Gram-negative bacteria. Cefradin may also interfere with autolysin inhibitors.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.