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中文名称英文名称CAS 编号规格目录价所属品牌订货号
盐酸拓扑替康Topotecan hydrochloride hydrate123948-87-810MG623.00SIGMAT2705
盐酸拓扑替康Topotecan hydrochloride hydrate123948-87-850MG2,410.00SIGMAT2705
盐酸拓扑替康Topotecan hydrochloride hydrate123948-87-81G17,300.00SIGMAT2705
品牌SIGMA
产品名称 盐酸拓扑替康 : Topotecan hydrochloride hydrate ——【产品编号:SIGMA-T2705】
CAS编号123948-87-8
别名拓扑替康盐酸盐,NSC-609669 hydrochloride hydrate,SKF-104864A hydrochloride hydrate,hycamptamine hydrochloride hydrate
级别科学级
纯度&分析≥98% (HPLC and enzymatic)
Tips此产品是一种拓扑异构酶抑制剂和凋亡诱导剂。是一种强有力的抗肿瘤原料。
分子式 C23H23N3O5 · xHCl · yH2O
分子量421.45
储存条件-20 °C 低温冷冻保存。
性质
assay   ≥98% (HPLC and enzymatic)
form   powder
storage condition   desiccated
  protect from light
color   yellow
solubility   DMSO: ≥20 mg/mL
storage temp.   −20°C
原产地美国
描述

Biochem/physiol Actions

Topotecan is a topoisomerase I inhibitor and an apoptosis inducer. It is a potent antineoplastic agent.

供货状态True
参考文献

Topoisomerase I inhibition with topotecan: pharmacologic and clinical issues. Arun, B., and Frenkel, E.P. Expert Opin. Pharmacother. 2, 491-505, (2001)

Topotecan for the treatment of small-cell lung cancer. Nicum, S.J., and O'Brien, M.E. Expert Rev. Anticancer Ther. 7, 795-801, (2007)

Merck 14,9548

类型BSZH 生物化学研究
安全信息
符号  GHS08
信号词  Warning
危险声明  H341
警示性声明  P281
风险声明 (欧洲)  46-48
安全声明 (欧洲)  22-36
RIDADR  UN 2811 6.1/PG 3
WGK德国  3