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中文名称英文名称CAS 编号规格目录价所属品牌订货号
细胞色素 C(源于马心脏)Cytochrome c from equine heart9007-43-625MG¥658.00SIGMAC7752
细胞色素 C(源于马心脏)Cytochrome c from equine heart9007-43-6100MG¥1,592.00SIGMAC7752
细胞色素 C(源于马心脏)Cytochrome c from equine heart9007-43-61G¥12,300.00SIGMAC7752
细胞色素 C(源于马心脏)Cytochrome c from equine heart9007-43-65G¥40,423.00SIGMAC7752
品牌SIGMA
产品名称 细胞色素 C(源于马心脏) : Cytochrome c from equine heart ——【产品编号:SIGMA-C7752】
CAS编号9007-43-6
别名马细胞色素C
级别科学级
纯度&分析≥95% based on Mol. Wt. 12,384 basis
Tips细胞色素 C是一种电子负载线粒体蛋白质,是一​种通用的呼吸作用催化剂,能在呼吸底物和氧之间形成必​要的电子桥。
分子式N/A
分子量N/A
储存条件-20 °C 低温冷冻保存。
性质
Quality Level PREMIUM
assay ≥95% (SDS-PAGE)
  ≥95% based on Mol. Wt. 12,384 basis
storage temp. −20°C
原产地美国
描述

Biochem/physiol Actions

细胞色素 C 主要被认为是一种电子负载线粒体蛋白质。细胞内的细胞​色素 C 在亚铁和铁价态之间转变使得它成为有效的生物电子传递​体,并在动植物细胞氧化中起关键作用。通常认为它是一​种通用的呼吸作用催化剂,能在呼吸底物和氧之间形成必​要的电子桥。

Preparation Note

Prepared with acetic acid without using TCA.

Application

Cytochrome c has been identified as an important mediator in apoptotic pathways. The release of mitochondrial cytochrome c into the cytoplasm stimulates apoptosis and is commonly used as an indicator of the apoptotic process in the cell. Investigation on the effect of Paris saponin I (PS I) on human gastric carcinoma cell growth (SGC7901 cells) have shown an elevated level cytoplasmic cytochrome c. Results are an inhibition of proliferation in SGC7901 cells by inducing mitochondria-dependent apoptosis through cytochrome c.

 

The specific sites and extent of oxidation in horse cytochrome c treated with H2O2 and UV were characterized. It was suggested that the state of these sites could be used as a biomarker for the oxidative environment in a cell.

供货状态True
参考文献

Paris chinensis dioscin induces G2/M cell cycle arrest and apoptosis in human gastric cancer SGC-7901 cells. Gao L., et al. World J. Gastroenterol. 17, 4389-4395, (2011)

Novel biomarkers of protein oxidation sites and degrees using horse cytochrome c as the target by mass spectrometry Zong, W., et al. Spectrochim. Acta A 78, 1581-1586, (2011)

Merck 14,2791

类型生物化学
安全信息
个人防护装备 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK德国 3
RTECS HA5365000