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中文名称英文名称CAS 编号规格目录价所属品牌订货号
利福平Rifampicin13292-46-1250MG¥478.00SIGMAR3501
利福平Rifampicin13292-46-11G¥1,265.00SIGMAR3501
利福平Rifampicin13292-46-15G¥3,970.00SIGMAR3501
利福平Rifampicin13292-46-125G¥15,500.00SIGMAR3501
利福平Rifampicin13292-46-1100G¥43,000.00SIGMAR3501
品牌SIGMA
产品名称 利福平 : Rifampicin ——【产品编号:SIGMA-R3501】
CAS编号13292-46-1
别名3-(4-甲基-1-哌嗪基亚胺甲基)利福霉素SV,利米定,甲哌利福霉素,甲哌利福霉素
级别科学级
纯度&分析≥97% (HPLC), powder
Tips抑制DNA的重组和蛋白质插进成熟的病毒颗粒,靠结合RNA聚合酶的β-亚单元抑制RNA合成的起始。
分子式C43H58N4O12
分子量822.94
储存条件-20 °C 低温冷冻保存。
性质
assay   ≥97% (HPLC)
form   powder
color   faint-orange to red-brown
solubility   H2O: soluble1.3 mg/mL (pH 4.3)
  DMSO: soluble100 mg/mL
  H2O: soluble2.5 mg/mL at 25 °C (pH 7.3)
storage temp.   −20°C
原产地美国
描述

Biochem/physiol Actions

Inhibits the assembly of DNA and protein into mature virus particles.

Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase.

供货状态True
参考文献

Wehrli, W., Rifampin: mechanisms of action and resistance. Rev. Infect. Dis. 5, S407-S411, (1983)

Mustaev, A., Topology of the RNA polymerase active center probed by chimeric rifampicin-nucleotide compounds. Proc. Natl. Acad. Sci. U. S. A. 91, 12036, (1994)

Wegrzyn, A., et al., Differential inhibition of transcription from sigma70- and sigma32-dependent promoters by rifampicin. FEBS Lett. 440, 172-174, (1998)

Pfannschmidt, T., et al., The A and B forms of plastid DNA-dependent RNA polymerase from mustard (Sinapis alba L.) transcribe the same genes in a different developmental context. Mol. Gen. Genet. 257, 35-44, (1997)

Sodeik, B., et al., Assembly of vaccinia virus: effects of rifampin on the intracellular distribution of viral protein p65. J. Virol. 68, 1103-1114, (1994)

Tomiyama, T., et al., Rifampicin prevents the aggregation and neurotoxicity of amyloid beta protein in vitro. Biochem. Biophys. Res. Commun. 204, 76-83, (1994)

Merck 14,8216

类型抗生素
安全信息
符号  GHS07  
信号词  Warning
危险声明  H302-H315-H319-H335
警示性声明  P261-P305 + P351 + P338
个人防护装备  dust mask type N95 (US), Eyeshields, Gloves
危害码  Xn
风险声明  22-36/37/38
安全声明  26-36
WGK德国  3
RTECS  VJ7000000