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中文名称英文名称CAS 编号规格目录价所属品牌订货号
β-雌二醇β-Estradiol50-28-21MG¥636.00SIGMAE2257
β-雌二醇β-Estradiol50-28-25MG¥2,571.00SIGMAE2257
β-雌二醇β-Estradiol50-28-225MG¥9,769.00SIGMAE2257
β-雌二醇β-Estradiol50-28-2100MG¥23,640.00SIGMAE2257
β-雌二醇β-Estradiol50-28-21G¥127,310.00SIGMAE2257
品牌SIGMA
产品名称 β-雌二醇 : β-Estradiol ——【产品编号:SIGMA-E2257】
CAS编号50-28-2
别名1,3,5-雌甾三烯-3,17β-二醇,17β-雌二醇,3,17β-二羟基-1,3,5(10)-雌甾三烯,雌二醇,Oestradiol,beta-Estradiol
级别细胞培养级
纯度&分析≥98% (TLC),γ-irradiated,BioXtra,suitable for cell culture
Tips此产品经伽马光预处理,并已通过细胞培养测试,可用于细胞培养、分化和转化、诱导等研究。
分子式C18H24O2
分子量272.38
储存条件常温避光保存。
性质
sterility γ-irradiated
product line BioXtra
form powder
potency 0.2-10 ng/mL
mp 176-180 °C(lit.)
suitability suitable for cell culture
原产地美国
描述

Application

β-雌二醇可用于研究细胞分化和转化(肿瘤发生)。

Reconstitution

要制备 20μg/mL 的储存液,可加入 1mL 无水乙醇,温和搅拌使之溶解,在搅拌下加入 49mL 无菌培养基。

Physical form

室温下为粉末状;分成小份冻存,以避免使用时反复冷冻/解冻

Biochem/physiol Actions

由绝经前卵巢分泌的主要雌激素。雌激素在胚胎形成中以及在青春期,通过调控基因转录,并因此调控蛋白合成,从而指导女性表型的发展。它还可诱导促性腺激素的生成,继而诱导排卵。暴露于雌二醇将增加乳腺癌的发病率以及增加增生。

供货状态True
参考文献

Yu, Y., et al., MAPK-mediated Phosphorylation of GATA-1 Promotes Bcl-XL Expression and Cell Survival J. Biol. Chem. 280, 29533-42, (2005)

Freret, S., et al., Reduction of body-weight gain enhances in vitro embryo production in overfed superovulated dairy heifers Reprod. 131, 783-94, (2006)

Alabraba, E.B., et al., Expression and functional consequences of oestrogen and progesterone receptors in human insulinomas Endocrinol. Relat. Cancer 14, 1081-8, (2007)

Spoerl, E., et al., Oestrogen-induced changes in biomechanics in the cornea as a possible reason for keratectasia Br. J. Ophthalmol. 91, 1547-50, (2007)

Zhang, L., et al., Adam12 Plays A Role During Uterine Decidualization In Mice. Cell Tissue Res. 338, 413-21, (2009)

Barceló-Fimbres, M., et al., Effects Of Phenazine Ethosulfate During Culture Of Bovine Embryos On Pregnancy Rate, Prenatal And Postnatal Development. Theriogenology 71, 355-68, (2009)

Nicodemo, D., et al., Frequency Of Aneuploidy In In Vitro-matured MII Oocytes And Corresponding First Polar Bodies In Two Dairy Cattle (Bos Taurus) Breeds As Determined By Dual-color Fluorescent In Situ Hybridization. Theriogenology 73, 523-9, (2010)

Beato, M., Gene regulation by steroid hormones. Cell 56, 335-344, (1989)

Yue, W., et al., Genotoxic metabolites of estradiol in breast: potential mechanism of estradiol induced carcinogenesis. J. Steroid Biochem. Mol. Biol. 86, 477-486, (2003)

Shao, W., and Brown, M., Advances in estrogen receptor biology: prospects for improvements in targeted breast cancer therapy. Breast Cancer Res. 6, 39-52, (2003)

Merck 14,3703

Beil. 6,IV,6611

Corp MSDS 1 (1), 1534:B / FT-IR 2 (3), 4237:B / FT-IR 1 (2), 1055:C / FT-NMR 1 (3), 589:B / RegBook 1 (2), 2865:K / Sax 6, 1298 / Sigma FT-IR 1 (1), 1243:D / Structure Index 1, 459:D:2

类型BSZH 有机化学试剂
安全信息
符号 GHS08
信号词 Danger
危险声明 H351-H360Fd-H362
警示性声明 P201-P263-P281-P308 + P313
个人防护装备 Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
危害码 T
风险声明 45
安全声明 53-45
WGK德国 3
RTECS KG2975000