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中文名称英文名称CAS 编号规格目录价所属品牌订货号
链脲菌素Streptozocin18883-66-4100MG¥694.65SIGMAS0130
链脲菌素Streptozocin18883-66-41G¥3,214.55SIGMAS0130
链脲菌素Streptozocin18883-66-45G¥14,040.54SIGMAS0130
品牌SIGMA
产品名称 链脲菌素 : Streptozocin ——【产品编号:SIGMA-S0130】
CAS编号18883-66-4
别名链脲佐菌素,链脲霉素,链唑霉素,链佐霉素,N-(Methylnitrosocarbamoyl)-α-D-glucosamine,Streptozotocin,STZ
级别科学级
纯度&分析≥75% α-anomer basis, ≥98% (HPLC), powder
Tips一种含N-亚硝基的化合物,在胰腺胰岛充当一氧化氮的供体。诱导产生糖尿病动物模式的胰岛素分泌细胞的死亡。
分子式 C8H15N3O7
分子量265.22
储存条件-20 °C 低温冷冻保存。
性质
assay   ≥75% α-anomer basis
  ≥98% (HPLC)
form   powder
color   white to off-white
mp   121 °C (dec.)(lit.)
storage temp.   −20°C
原产地美国
描述

Application

Streptozocin is used to induce Type 1 diabetes for medical research.

General description

Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Streptozocin, a diabetagen, is especially toxic to pancreatic islet insulin-producing β-cells. It is toxic to GLUT2 positive neuroendocrine tumor cells.

Other Notes

Mixed anomers

Biochem/physiol Actions

An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage.1 Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.

供货状态True
参考文献

1. Bennett, R.A., and Pegg, A.E., Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res. 41, 2786, (1981)

Wang Z, and Gleichmann H., GLUT2 in pancreatic islets: crucial target molecule in diabetes induced with multiple low doses of streptozotocin in mice Diabetes 47, 50-56, (1998)

Lenzen S., The mechanisms of alloxan- and streptozotocin-induced diabetes Diabetologia 51, 216-226, (2008)

Banerjee, S.K., et al., SGLT1 Is A Novel Cardiac Glucose Transporter That Is Perturbed In Disease States. Cardiovasc. Res. 84, 111-8, (2009)

Moss, J.B., et al., Regeneration Of The Pancreas In Adult Zebrafish. Diabetes 58, 1844-51, (2009)

Al-Khalifa, A., et al., Therapeutic Role Of Low-carbohydrate Ketogenic Diet In Diabetes. Nutrition 25, 1177-85, (2009)

Robertson, S.D., et al., Insulin Reveals Akt Signaling As A Novel Regulator Of Norepinephrine Transporter Trafficking And Norepinephrine Homeostasis. J. Neurosci. 30, 11305-16, (2010)

Anthonisen, E.H., et al., Nuclear Receptor Liver X Receptor Is O-GlcNAc-modified In Response To Glucose. J. Thorac. Cardiovasc. Surg. 285, 1607-15, (2010)

Rao, V.R., et al., Delivery Of SAR 1118 To The Retina Via Ophthalmic Drops And Its Effectiveness In A Rat Streptozotocin (STZ) Model Of Diabetic Retinopathy (DR). Invest. Ophthalmol. Vis. Sci. 51, 5198-204, (2010)

Margoni, A., et al., Serum Leptin, Adiponectin And Tumor Necrosis Factor-α In Hyperlipidemic Rats With/without Concomitant Diabetes Mellitus. Mol. Med. 17, 36-40, (2011)

Bolzan, A.D., and Bianchi, M.S., Clastogenic effects of streptozotocin on human colon cancer cell lines with gene amplification. J. Environ. Pathol. Toxicol. Oncol. 22, 281-286, (2003)

Oberg, K., Chemotherapy and biotherapy in the treatment of neuroendocrine tumours. Ann. Oncol. 12, S111-S114, (2001)

Szkudelski T., The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol. Res. 50, 537-546, (2001)

Merck 14,8832

Corp MSDS 1 (2), 3177:D / FT-IR 2 (1), 1366:B / FT-NMR 1 (1), 1313:B / RegBook 1 (1), 945:A / Sax 6, 2469 / Structure Index 1, 147:D:1

类型抗生素
安全信息
符号  GHS08
信号词  Danger
危险声明  H350
警示性声明  P201-P308 + P313
个人防护装备  Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
危害码  Xn
风险声明  40
安全声明  36/37
WGK德国  3
RTECS  LZ5775000