中文名称英文名称CAS 编号规格所属品牌订货号
多粘菌素 B 硫酸盐Polymyxin B sulfate salt1405-20-5100MGSIGMAP4119
多粘菌素 B 硫酸盐Polymyxin B sulfate salt1405-20-51GSIGMAP4119
多粘菌素 B 硫酸盐Polymyxin B sulfate salt1405-20-55GSIGMAP4119
多粘菌素 B 硫酸盐Polymyxin B sulfate salt1405-20-525GSIGMAP4119
品牌SIGMA
产品名称 多粘菌素 B 硫酸盐 : Polymyxin B sulfate salt ——【产品编号:SIGMA-P4119】
CAS编号1405-20-5
别名多粘菌素B硫酸盐,多粘菌素硫酸盐,硫酸多粘菌素B
级别生物技术级
纯度&分析Biotechnology Performance Certified,> 6000 USP UNITS/MG
Tips多粘菌素B为抗革兰阴性杆菌多肽类抗生素,可以改变膜结构使小分子物质泄漏而抑制革兰氏阴性菌的生长。
分子式C55H96N16O13 · 2H2SO4
分子量1385.61
储存条件2-8 °C 冷藏保存。
性质
APPEARANCE WHITE TO LIGHT YELLOW POWDER
SOLUBILITY CLEAR TO VERY SLIGHTLY HAZY COLORLESS TO YELLOW SOLUTION AT 50 MG/ML IN WATER
IR SPECTRUM CONSISTENT WITH STRUCTURE
POTENCY > 6000 USP UNITS/MG
ENDOTOXIN ASSAY < OR = 10 EU/MG
CELL CULTURE TEST PASSES
原产地美国
描述

Biochem/physiol Actions

Antibiotic with bactericidal action on E. coli.3,4 Binds to the lipid A portion of bacterial lipopolysaccharides.5 Induces pore formation in the membranes of cortex cells from excised sorghum roots.6
Mode of Action: Binds to and interferes with the permeability of the cytoplasmic membrane.
Antimicrobial spectrum: Gram-negative bacteria.

Polymyxin B destabilizes and disrupts cell membrane integrity which allows the leakage of cellular molecules and inhibits cellular respiration. In human dendritic cells, DCs incubated with polymyxin B up-regulate the expression of HLA class I and II, the co-stimulatory CD86 molecule, and show an increase in the fraction of adherent cells1. In the rat model, Polymyxin B caused a significant reduction in plasma endotoxin and tumour necrosis factor α (TNF-α) concentration.2.

Other Notes

Mixture of Polymyxin B1 and B2 sulfate.

Application

Polymyxin B is a lipopolysaccharide binding antibiotic derived from Bacillus polymyxa. It is primarily used against Gram-negative bacteria. It is used to mature dendritic cells in culture and inactivate potential lipopolysaccharide contaminations . Polymyxin B is used to study potential treatments for septic shock 1 and for antimicrobial susceptibility testing of organisms such as Pseudomonas aeruginosa 2. Polymyxin B sulfate salt is biotechnology performance certified.

供货状态True
参考文献

1. Barbara Valentinis, Alessandro Bianchi, et al., Direct effects of polymyxin B on human dendritic cells maturation. The role of IκB-α/NF-κB and ERK1/2 pathways and adhesion. J. Biol. Chem. 280, 14264-14271, (2005)

2. Andrea Giacometti, Oscar Cirioni, et al., Therapeutic efficacy of intraperitoneal polymyxin B and polymyxin-like peptides alone or combined with levofloxacin in rat models of septic shock. J. Antimicrob. Chemother. 49, 193-196, (2002)

3. Cornu, J. Ann. Microbiol. 131B, 121, (1980)

4. Storm, D.R., et al. Annu. Rev. Biochem. 46, 723, (1977)

5. Morrison, D.C. and Jacobs, D.M. Immunochemistry 13, 813, (1976)

6. Lerner, H.R., et al. Physiol. Plant. 57, 90, (1983)

Michael Hogardt, Sabine Schmoldt, et al., Pitfalls of polymyxin antimicrobial susceptibility testing of Pseudomonas aeruginosa isolated from cystic fibrosis patients. J. Antimicrob. Chemother. 54, 1057-1061, (2004)

Merck 14,7573

类型抗生素
安全信息
符号  GHS07
信号词  Warning
危险声明  H302
个人防护装备  dust mask type N95 (US), Eyeshields, Gloves
危害码  Xn
风险声明  22
安全声明  22-24/25
WGK德国  3
RTECS  TR1150000