中文名称英文名称CAS 编号规格所属品牌订货号
氯唑西林钠Cloxacillin sodium salt monohydrate7081-44-91GSIGMAC9393
氯唑西林钠Cloxacillin sodium salt monohydrate7081-44-95GSIGMAC9393
氯唑西林钠Cloxacillin sodium salt monohydrate7081-44-925GSIGMAC9393
品牌SIGMA
产品名称 氯唑西林钠 : Cloxacillin sodium salt monohydrate ——【产品编号:SIGMA-C9393】
CAS编号7081-44-9
别名邻氯青霉素钠
级别科学级
纯度&分析β-lactamase-resistant antibiotic
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分子式C19H17ClN3O5SNa · H2O
分子量475.88
储存条件2-8 °C 冷藏保存。
性质

本品为半合成青霉素,具有耐酸、耐青霉素酶的特点,对革兰阳性球菌和奈瑟菌有抗菌活性,对葡萄球菌属(包括金黄色葡萄球菌和凝固酶阴性葡萄球菌)产酶株的抗菌活性较苯唑西林强,但对青霉素敏感葡萄球菌和各种链球菌的抗菌作用较青霉素为弱,对甲氧西林耐药葡萄球菌无效。

form   solid
solubility   H2O: soluble50 mg/mL
Mode of action   cell wall synthesis | interferes
antibiotic activity spectrum   Gram-positive bacteria
storage temp.   2-8°C

原产地美国
描述

Application
Cloxacillin is effective against infections caused by penicillin G-resistant staphylococci.[1] It was used in studies of topical antibacterial agents for burn and crush wounds.[2]
Biochem/physiol Actions
Cloxacillin is a semi-synthetic antibiotic and a chlorinated derivative of oxacillin. It inhibits the last stage of bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), which results in cell lysis. Cell lysis is mediated by bacterial cell wall autolytic enzymes. Cloxacillin is often used as AmpC β-lactamase inhibitor in combination with β-lactam antibiotics.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.

供货状态True
参考文献N/A
类型抗生素
安全信息

符号  GHS07GHS08  GHS07, GHS08
信号词  Danger
危害声明  H315-H317-H319-H334-H335
警示性声明  P261-P280-P305 + P351 + P338-P342 + P311
个人防护装备  dust mask type N95 (US), Eyeshields, Faceshields, Gloves
危害码 (欧洲)  Xn
风险声明 (欧洲)  36/37/38-42/43
安全声明 (欧洲)  26-36
RIDADR  NONH for all modes of transport
WGK德国  2
RTECS  XH8920000