中文名称英文名称CAS 编号规格所属品牌订货号
L-甲状腺素L-Thyroxine51-48-9100MGSIGMAT2376
L-甲状腺素L-Thyroxine51-48-9500MGSIGMAT2376
L-甲状腺素L-Thyroxine51-48-91GSIGMAT2376
L-甲状腺素L-Thyroxine51-48-95GSIGMAT2376
品牌SIGMA
产品名称 L-甲状腺素 : L-Thyroxine ——【产品编号:SIGMA-T2376】
CAS编号51-48-9
别名2-甲状腺素 O-(4-羟基-3,5-二碘苯基)-3,5-二碘-L-酪氨酸 D-α-生育酚 左旋甲状腺素 3,5,3',5'-四碘甲状腺胺酸 3,3',5,5'-Tetraiodo-L-thyronine
级别科学级
纯度&分析≥98% (HPLC)
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分子式HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H
分子量776.87
储存条件常温避光保存。
性质

用途及描述:

科研试剂,广泛应用于分子生物学,药理学等科研方面。本品为甲状腺激素类药,在体内转变成三碘甲状腺原氨酸(T3)而活性增强,具有维持人体正常生长发育、促进代谢、增加产热和提高交感-肾上腺系统感受性等作用
外观:白色结晶性粉末
储存条件:室温,避光防潮密闭干燥。

~InChI Key   XUIIKFGFIJCVMT-LBPRGKRZSA-N
assay   ≥98% (HPLC)
mp   223 °C (dec.)(lit.)

原产地美国
描述

Biochem/physiol Actions
L甲状腺素 (T4) 和三碘代-L-甲状腺原氨酸 (T3) 为含碘激素,由甲状腺卵泡细胞中的甲状腺球蛋白制备。这些激素对代谢率的刺激以及对生长发展的调节似乎归因于它们对 DNA 转录的作用,进而影响蛋白质的合成。
L-Thyroxine is an iodine containing hormone produced from thyroglobulin in the thyroid follicular cells. L-Thyroxine reduces total cholesterol level, low-density lipoprotein cholesterol as well as waist to hip ratio in subclinical hypothyroidism pateints. Hence, facilitates in improving cardiovascular risk factor as well as can enhance symptoms of tiredness.[2]

Bottomless glass bottle. Contents are inside inserted fused cone.
Preparation Note
L-Thyroxine dissolves in 4M ammonium hydroxide in Methanol at 50 mg/ml to yield a clear to hazy yellow to dark yellow solution.


Application
L-Thyroxine was used to study the light-induced hormone conversion of T4 to T3 in regulation of photoperiodic response of gonads in Japanese quail.[1] The product was used as a test compound for studying the impact of numerous hormones on the surface morphology of rat testicular cells in culture.[3]


Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. T2376.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

供货状态True
参考文献N/A
类型抗生素
安全信息

个人防护装备  Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RIDADR  NONH for all modes of transport
WGK德国  3
RTECS  YP2833500