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中文名称英文名称CAS 编号规格目录价所属品牌订货号
还原型辅酶 I(NADH,二钠盐)β-Nicotinamide adenine dinucleotide, reduced disodium salt hydrate606-68-8100MG¥382.00SIGMAN8129
还原型辅酶 I(NADH,二钠盐)β-Nicotinamide adenine dinucleotide, reduced disodium salt hydrate606-68-8500MG¥900.00SIGMAN8129
还原型辅酶 I(NADH,二钠盐)β-Nicotinamide adenine dinucleotide, reduced disodium salt hydrate606-68-81G¥1,291.00SIGMAN8129
还原型辅酶 I(NADH,二钠盐)β-Nicotinamide adenine dinucleotide, reduced disodium salt hydrate606-68-85G¥5,785.00SIGMAN8129
还原型辅酶 I(NADH,二钠盐)β-Nicotinamide adenine dinucleotide, reduced disodium salt hydrate606-68-825G¥25,450.00SIGMAN8129
品牌SIGMA
产品名称 还原型辅酶 I(NADH,二钠盐) : β-Nicotinamide adenine dinucleotide, reduced disodium salt hydrate ——【产品编号:SIGMA-N8129】
CAS编号606-68-8
别名还原型辅酶 I 二钠盐,β-NADH,β-DPNH,DPNH,Diphosphopyridine nucleotide,reduced form NADH
级别科学级
纯度&分析≥97% (HPLC)
Tips还原型 β-烟酰胺腺嘌呤二核苷酸二钠盐,水合物。
分子式  C21H27N7Na2O14P2 · xH2O
分子量709.40 (anhydrous basis)
储存条件-20 °C 低温冷冻保存。
性质
Quality Level PREMIUM
assay ≥97% (HPLC)
  ≥97% (spectrophotometric assay)
storage temp. −20°C
原产地美国
描述

Biochem/physiol Actions

NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, beta-oxidation and the citric acid cycle (Krebs cycle, TCA cycle). It participates in cell signaling events as well, for example as a substrate for the poly (ADP-ribose) polymerases (PARPs) during the DNA damage response. The NAD+/NADH dependent sirtuins play key roles in stress responses during events involving energy metabolism, with implications in cancer biology, diabetes and neurodegenerative disease.
As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.

包装

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Application

β-Nicotinamide adenine dinucleotide (NAD+) and β-Nicotinamide adenine dinucleotide, reduced (NADH) comprise a coenzyme redox pair (NAD+:NADH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. In addition to its redox function, NAD+/NADH is a donor of ADP-ribose units in ADP-ribosylaton (ADP-ribosyltransferases; poly(ADP-ribose) polymerases ) reactions and a precursor of cyclic ADP-ribose (ADP-ribosyl cyclases).

供货状态True
参考文献

Ying W., NAD+ and NADH in cellular functions and cell death. Front. Biosci. 11, 3129-3148, (2006)

Lin H., Nicotinamide adenine dinucleotide: beyond a redox coenzyme. Org. Biomolecular Chem. 5, 2541-2554, (2007)

Imai S., "Clocks" in the NAD World: NAD as a metabolic oscillator for the regulation of metabolism and aging. Biochim. Biophys. Acta 1804, 1584-1590, (2010)

Ebstein RP, Mankuta D, et al., Are retinoids potential therapeutic agents in disorders of social cognition including autism? FEBS Lett. 585, 1529-1536, (2011)

Hottiger MO., ADP-ribosylation of histones by ARTD1: an additional module of the histone code? FEBS Lett. 585, 1595-1599, (2011)

Grahnert A, Grahnert A, et al., Review: NAD +: a modulator of immune functions. Innate Immunity 17, 212-233, (2011)

Li X, Kazgan N., Mammalian sirtuins and energy metabolism. Int. J. Biol. Sci. 7, 575-587, (2011)

Fabricio, G., et al., PARPs and the DNA damage response. Carcinogenesis 25, (2012)

Martinez-Pastor, B. and Mostoslavsky, R., Sirtuins, metabolism, and cancer. Front. Pharmacol. 3, 1-7, (2012)

类型酶 & 辅酶
安全信息
个人防护装备 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK德国 3