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中文名称英文名称CAS 编号规格目录价所属品牌订货号
D-2-脱氧葡萄糖2-Deoxy-D-glucose154-17-61G¥565.00SIGMAD6134
D-2-脱氧葡萄糖2-Deoxy-D-glucose154-17-65G¥2,000.00SIGMAD6134
D-2-脱氧葡萄糖2-Deoxy-D-glucose154-17-625G¥9,200.00SIGMAD6134
D-2-脱氧葡萄糖2-Deoxy-D-glucose154-17-6100G¥24,800.00SIGMAD6134
品牌SIGMA
产品名称 D-2-脱氧葡萄糖 : 2-Deoxy-D-glucose ——【产品编号:SIGMA-D6134】
CAS编号154-17-6
别名2-脱氧-D-葡萄糖,2-脱氧-D-葡糖,2-去氧-D-葡萄糖,2-脱氧葡萄糖,2-DG
级别科学级
纯度&分析N/A
TipsN/A
分子式 C6H12O5
分子量164.16
储存条件常温避光保存。
性质
Appearance (Color) White
Appearance (Form) Crystalline Powder
Solubility (Color) Colorless
Solubility (Turbidity) Clear
  at 3.3 g plus 10 ml of H2O
Carbon 43.5 - 44.5 %
  (As is)
Specific Rotation 46 - 48 °
  (c = 2 in H2O at 20 deg C)
Infrared spectrum Conforms to Structure
Purity (GC) ≥99 %
原产地美国
描述

Preparation Note

A further purification of the Grade II material by recrystallization.

Biochem/physiol Actions

2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.1

供货状态True
参考文献

1. Wang, Q. et al., 2-Deoxy-D-glucose treatment of endothelial cells induces autophagy by reactive oxygen species-mediated activation of the AMP-activated protein kinase. PLoS ONE 6, e17234, (2011)

Merck 14,2904

Beil. 1,IV,4282

FT-IR 2 (1), 276:B / FT-IR 1 (1), 192:D / FT-NMR 1 (1), 296:B / IR-Spectra (2), 108:B / IR-Spectra (3), 116:F / NMR-Reference 2 (2), 909:B / RegBook 1 (1), 191:G / Sax 6, 867 / Sigma FT-IR 1 (1), 1054:B / Structure Index 1, 26:D:1

类型BSZH 糖类
安全信息
个人防护装备 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK德国 3