中文名称英文名称CAS 编号规格所属品牌订货号
庆大霉素硫酸盐Gentamicin sulfate salt1405-41-01GSIGMA-ALDRICHG3632
庆大霉素硫酸盐Gentamicin sulfate salt1405-41-05GSIGMA-ALDRICHG3632
庆大霉素硫酸盐Gentamicin sulfate salt1405-41-025GSIGMA-ALDRICHG3632
庆大霉素硫酸盐Gentamicin sulfate salt1405-41-0100GSIGMA-ALDRICHG3632
品牌SIGMA-ALDRICH
产品名称 庆大霉素硫酸盐 : Gentamicin sulfate salt ——【产品编号:SIGMA-ALDRICH-G3632】
CAS编号1405-41-0
别名硫酸庆大霉素,艮他霉素硫酸盐,正大霉素硫酸盐
级别科学级
纯度&分析potency: ≥590 μg Gentamicin base per mg
Tips庆大霉素靠结合到30S核糖体亚单位上引起密码读错,阻断肽酰-tRNA(peptidyl-tRNA)从受体位点到供体点点的转移。
分子式N/A
分子量N/A
储存条件2-8 °C 冷藏保存。
性质
Quality Level PREMIUM
potency ≥590 μg Gentamicin base per mg
shelf life 2 yr at 2-8 °C ( for sterile filtered solutions.)
concentration 50 μg/mL in H2O ( is the recommended working concentration for eukaryotic cell culture)
storage temp. 2-8°C
原产地美国
描述

Application

Used as a selection agent (gentamicin-resistance gene) in molecular biology applications.

Biochem/physiol Actions

Mode of action: Gentamicin causes codon misreading by binding to the 30S ribosomal subunit, blocking the translocation of peptidyl-tRNA from the acceptor site to the donor site.1,2 The bactericidal effect of gentamicin on Pseudomonas aeruginosa is exerted by the binding of gentamicin to the outer membrane, where it displaces natural cations, destabilizes the membrane, and forms holes in the cell surface.3
Antimicrobial spectrum: Gram-negative bacteria, Staphylococcus aureus and other Gram-positive bacteria.

供货状态True
参考文献

1. Korzybski, T., et al. Antibiotics: origin, nature, and properties Washington, DC , (1977), 712-723

2. Lorian, V. (ed.) Antibiotics in Laboratory Medicine 2nd ed., Baltimore, MD , (1986), 694-696

3. Kadurugamuwa, J., et al., Surface action of gentamicin on Pseudomonas aeruginosa J. Bacteriol. 175, 5798-5805, (1993)

Merck 14,4392

类型抗生素
安全信息
符号 GHS08
信号词 Danger
危险声明 H317-H334
警示性声明 P261-P280-P342 + P311
个人防护装备 dust mask type N95 (US), Eyeshields, Faceshields, Gloves
危害码 Xn
风险声明 42/43
安全声明 22-36/37-45
WGK德国 2
RTECS LY2625000