性质 |
Chlorpromazine is a compound that is used in cell signaling and neuroscience research. It is a dopamine inhibitor, notably at the D2-dopaminergic receptor. It also has a-adrenergic blocking activity and stimulates prolactin release. The antifungal properties of chlorpromazine and other compounds has been reviewed. The role of chlorpromazine and other tricyclic compounds as inhibitors of neuronal voltagegated K channels has been discussed.
The use of chlorpromazine (0 - 0.2 mM) to induce stress in E. coli to study regulation of the RcsCB His-Asp phosphorelay system has been described. The effect of chlorpromazine (1 mM) and other dopamine-active drugs on the production of oxytocin and vasopressin in rat neurohypophyseal tissue cultures has been studied. Chlorpromazine has been used to probe long-term potentiation of corticostriatal synaptic transmission in rat. Chlorpromazine (12 or 25 mM) has been shown to limit lipid accumulation in the human breast cell line HBL-100, as initially induced by tetraphenylphosphonium chloride.
An analytical method for chlorpromazine that couples high performance liquid chromatography to inductively coupled plasma mass spectroscopy has been described.
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Merck 14,2185
Beil. 27,IV,1300
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