Chlorpromazine is a compound that is used in cell signaling and neuroscience research. It is a dopamine inhibitor, notably at the D2-dopaminergic receptor. It also has a-adrenergic blocking activity and stimulates prolactin release. The antifungal properties of chlorpromazine and other compounds has been reviewed. The role of chlorpromazine and other tricyclic compounds as inhibitors of neuronal voltagegated K channels has been discussed.

The use of chlorpromazine (0 - 0.2 mM) to induce stress in E. coli to study regulation of the RcsCB His-Asp phosphorelay system has been described. The effect of chlorpromazine (1 mM) and other dopamine-active drugs on the production of oxytocin and vasopressin in rat neurohypophyseal tissue cultures has been studied. Chlorpromazine has been used to probe long-term potentiation of corticostriatal synaptic transmission in rat. Chlorpromazine (12 or 25 mM) has been shown to limit lipid accumulation in the human breast cell line HBL-100, as initially induced by tetraphenylphosphonium chloride.

An analytical method for chlorpromazine that couples high performance liquid chromatography to inductively coupled plasma mass spectroscopy has been described.

Application

在血红蛋白和过氧化物酶的微量测定中替代联苯胺、邻联茴香胺和邻联甲苯胺。

Biochem/physiol Actions

吩噻嗪类抗精神病药;D₂ 多巴胺受体拮抗剂，H₁ 组胺受体拮抗剂;抑制钙调蛋白依赖性环核苷酸磷酸二酯酶和一氧化氮合成酶的活化。

氯丙嗪表现出对白血病细胞的细胞毒性和抗增殖活性，但是不会影响正常淋巴细胞的活力。

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Merck 14,2185

Beil. 27,IV,1300