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中文名称英文名称CAS 编号规格目录价所属品牌订货号
放线菌素 DActinomycin D50-76-01MG¥476.00BSZHA76021
放线菌素 DActinomycin D50-76-05MG¥2,094.00BSZHA76021
放线菌素 DActinomycin D50-76-025MG¥9,213.00BSZHA76021
放线菌素 DActinomycin D50-76-0100MG¥29,355.00BSZHA76021
放线菌素 DActinomycin D50-76-01G¥188,600.00BSZHA76021
品牌BSZH
产品名称 放线菌素 D : Actinomycin D ——【产品编号:BSZH-A76021】
CAS编号50-76-0
别名放线菌素 C1,放线菌素 IV,更生霉素
级别细胞培养级
纯度&分析 from Streptomyces sp, suitable for cell culture, ≥99%
Tips一种常用的研究级抗生素类制品,适用于科学研究、辅料、规模化生产等。
分子式 C62H86N12O16
分子量1255.42
储存条件2-8 °C 冷藏保存。
性质
biological source from Streptomyces sp.
assay ≥95%
form powder
color red, powder
mp 251-253
solubility ethanol, DMSO: soluble (Stable in aqueous solutions at 2-8 °C.)
suitability suitable for cell culture
storage temp. 2-8°C
原产地美国
描述

Application

Recommended for use in cell culture applications as a selection agent at 1 μg/ml.

Biochem/physiol Actions

An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes.

作用模式:与 DNA 结合并干扰 RNA 合成。

供货状态True
参考文献

Wadkins, R.M., Actinomycin D binding to single-stranded DNA: sequence specificity and hemi-intercalation model from fluorescence and 1H NMR spectroscopy. J. Mol. Biol. 262, 53, (1996)

Hu, B., et al., Kasabach-Merritt syndrome-associated kaposiform hemangioendothelioma successfully treated with cyclophosphamide, vincristine, and actinimycin D. J. Pediatr. Hematol. Oncol. 20, 567, (1998)

Glynn, J.M., et al., Apoptosis induced by Actinomycin D, Camptothecin or Aphidicolin can occur in all phases of the cell cycle. Biochem. Soc. Trans. 20, 84S, (1992)

Cohen, S.M., et al., Identification of chromosomal bands replicating early in the S phase of normal human fibroblasts. Exp. Cell Res. 254, 321, (1998)

Chen, H., et al., DNA bending and unwinding associated with actinomycin D antibiotics bound to partially overlapping sites on DNA. J. Mol. Biol. 258, 457, (1996)

Verma, R.S., Babu, A. Manual of Basic Techniques New York, NY , (1989)

Merck 14,2800

Beil. 27,IV,9642

Aldrich MSDS 1, 34:A / Corp MSDS 1 (1), 62:B / RegBook 1 (2), 2651:C / Sax 6, 134 / Sigma FT-IR 1 (1), 610:D / Structure Index 1, 417:B:6

类型抗生素
安全信息
符号 GHS06
信号词 Danger
危险声明 H300
警示性声明 P264-P301 + P310
个人防护装备 Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
危害码 T+
风险声明 28
安全声明 22-28-36/37-45
RIDADR UN 3462 6.1/PG 2
WGK德国 3
RTECS AU1575000