中文名称英文名称CAS 编号规格所属品牌订货号
二乙酰一肟2,3-Butanedione monoxime57-71-610GSIGMAB0753
二乙酰一肟2,3-Butanedione monoxime57-71-625GSIGMAB0753
二乙酰一肟2,3-Butanedione monoxime57-71-6100GSIGMAB0753
二乙酰一肟2,3-Butanedione monoxime57-71-6500GSIGMAB0753
二乙酰一肟2,3-Butanedione monoxime57-71-61KGSIGMAB0753
品牌SIGMA
产品名称 二乙酰一肟 : 2,3-Butanedione monoxime ——【产品编号:SIGMA-B0753】
CAS编号57-71-6
别名BDM, 联乙酰一肟,2,3-丁二酮一肟,双乙酰一肟,甲基肟乙基甲酮,丁二酮单肟,2,3-丁二酮肟,2,3-丁烷二酮一肟,肟乙基甲酮,丁二酮一肟,二甲基乙二酰一肟
级别科学级
纯度&分析≥98%
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分子式CH3C(=NOH)COCH3
分子量101.10
储存条件常温避光保存。
性质

assay   ≥98%
bp   185-186 °C(lit.)
mp   75-78 °C(lit.)

原产地美国
描述

Biochem/physiol Actions
DRK1 is a delayed rectifier (Kv2.1) cloned K+ channel from rat brain with consensus sites for protein kinase-dependent phosphorylation that might be expected to be functionally regulated by phosphorylation. 2,3-Butanedione monoxime (BDM) chemically removes phosphate groups from many proteins, and its action on DRK1 channels was examined after expression of DRK1 cRNA in Xenopus oocytes. In two-microelectrode voltage-clamp experiments, the application of 2,3-Butanedione monoxime to the bath inhibited DRK1 current (ki = 16.6 mM, H = 0.96) rapidly and reversibly, with a time course similar to the time course of solution change within the bath. DRK1 current was inhibited at all potentials; the time course of current activation, deactivation and inactivation were unaffected by 2,3-Butanedione monoxime. In inside-out patch-clamp experiments, the application of 2,3-Butanedione monoxime to the cytoplasmic surface similarly inhibited channel activity rapidly and reversibly (ki = 10.7 mM, H = 1.01) in the absence of rephosphorylating substrates. These results are inconsistent with a phosphatase effect, because such an effect should be irreversible in cell-free, ATP-free patches. Instead, the results suggest that 2,3-Butanedione monoxime can inhibit DRK1 channels directly from inside or outside of the membrane.


Features and Benefits
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法律信息
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供货状态True
参考文献N/A
类型抗生素
安全信息

个人防护装备  Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RIDADR  NONH for all modes of transport
WGK德国  3
RTECS  EK3150000