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中文名称英文名称CAS 编号规格目录价所属品牌订货号
透明质酸酶Hyaluronidase from bovine testes37326-33-350MG¥575.00SIGMAH3884
透明质酸酶Hyaluronidase from bovine testes37326-33-3100MG¥992.00SIGMAH3884
透明质酸酶Hyaluronidase from bovine testes37326-33-3500MG¥3,376.00SIGMAH3884
透明质酸酶Hyaluronidase from bovine testes37326-33-31G¥6,250.00SIGMAH3884
品牌SIGMA
产品名称 透明质酸酶 : Hyaluronidase from bovine testes ——【产品编号:SIGMA-H3884】
CAS编号37326-33-3
别名玻璃糖醛酸酶,玻璃酸酶,
级别科学级
纯度&分析Type IV-S, lyophilized powder (essentially salt-free), 750-3000 units/mg solid
Tips来源于牛睾丸。
分子式N/A
分子量N/A
储存条件-20 °C 低温冷冻保存。
性质
type Type IV-S
form lyophilized powder (essentially salt-free)
mol wt mol wt ~55 kDa (four subunits of 14 kDa each)
storage temp. −20°C
原产地美国
描述

Biochem/physiol Actions

Hyaluronidase degrades hyaluronan and has been found to be inappropriately regulated during cancer progression.1,2

这些酶可随机裂解透明质酸、软骨素和硫酸软骨素中的 β-N-乙酰己糖胺-[1→4] 糖苷键。

Unit Definition

One unit will cause a change in A600 of 0.330 per minute at pH 5.7 at 37 °C in a 2.0 ml reaction mixture (45 minute assay).

供货状态True
参考文献

1. W.B. Lokeshwar et al., Regulation of hyaluronidase activity by alternative mRNA splicing J. Biol. Chem. 277, 33654-33663, (2002)

2. K.S. Girish, K. Kemparaju, The magic glue hyaluronan and its eraser hyaluronidase: A biological overview Life Sci. 80, 1921-1943, (2007)

Kreger, S.T., and Voytik-Harbin, S.L., Hyaluronan concentration within a 3D collagen matrix modulates matrix viscoelasticity, but not fibroblast response. Matrix Biol. 28, 336-46, (2009)

Simpson, R.M., et al., Aging Fibroblasts Resist Phenotypic Maturation Because Of Impaired Hyaluronan-dependent CD44/epidermal Growth Factor Receptor Signaling. Am. J. Pathol. 176, 1215-28, (2010)

Werkmeister, E., et al., Collagenous Extracellular Matrix Of Cartilage Submitted To Mechanical Forces Studied By Second Harmonic Generation Microscopy. Photochem. Photobiol. 86, 302-10, (2010)

Abrishami, M., et al., Cryopreservation of immature porcine testis tissue to maintain its developmental potential after xenografting into recipient mice. Ther. Drug Monit. 73, 86-96, (2010)

Wang, C.C., et al., A role for VAMP8/endobrevin in surface deployment of the water channel aquaporin 2. Mol. Cancer Ther. 30, 333-43, (2010)

Meyer, K., Hoffman, P., Linker, A. The Enzymes 2nd ed.,, (1960) 4, 447

类型酶 & 辅酶
安全信息
个人防护装备 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
安全声明 22-24/25
WGK德国 3