| 品牌 |  |
| 产品名称 |
黄嘌呤氧化酶 ： Xanthine Oxidase from bovine milk ——【产品编号：SIGMA-X4500】
|
| CAS编号 | 9002-17-9 |
| 别名 | XOD，Xanthine:oxygen，oxidoreductase |
| 级别 | 科学级 |
| 纯度&分析 | Grade III, ammonium sulfate suspension, 1.0-2.0 units/mg protein |
| Tips | 来源于牛奶。 |
| 分子式 | N/A |
| 分子量 | N/A |
| 储存条件 | 2-8 °C 冷藏保存。 |
| 性质 |
|
type |
Grade III |
|
form |
ammonium sulfate suspension |
|
foreign activity |
uricase ≤0.1% |
|
storage temp. |
2-8°C |
|
| 原产地 | 美国 |
| 描述 |
Analysis Note
Protein determined by biuret
Biochem/physiol Actions
Xanthine oxidase is a molybdenum-containing enzyme that is found in the cytosol, and may be strongly inhibited by flavonoids.1,2 It plays a vital role in the metabolism of some drugs, as well as purines and pyrimidines.3 It is also known to be a biological source of reactive oxygen species.4
General description
Formerly E.C. 1.1.3.22
Preparation Note
Chromatographically purified
Unit Definition
One unit will convert 1.0 μmole of xanthine to uric acid per min at pH 7.5 at 25 °C. Approx. 50% of the activity is obtained with hypoxanthine as substrate.
Physical form
Suspension in 2.3 M (NH4)2SO4, 10 mM sodium phosphate buffer, pH 7.8, containing 1 mM EDTA and 1 mM sodium salicylate
|
| 供货状态 | True |
| 参考文献 |
1. A. Nagao et al., Inhibition of Xanthine Oxidase by Flavonoids Biosci. Biotechnol. Biochem. 63, 1787, (1999)
2. J. Aucamp et al., Inhibition of xanthine oxidase by catechins from tea (Camellia sinensis) Anticancer Res. 17, 4381, (1997)
3. T.A. Krenitsky et al., A comparison of the specificities of xanthine oxidase and aldehyde oxidase Arch. Biochem. Biophys. 150, 585, (1972)
4. Y. Ohta et al., Xanthine oxidase-derived reactive oxygen species contribute to the development of d-galactosamine-induced liver injury in rats Free Radic. Res. 41, 135, (2007)
Hickey, C.M., et al., Mitochondrial Ca2+ Activates A Cation Current In Aplysia Bag Cell Neurons. J. Autoimmun. 103, 1543-56, (2010)
|
| 类型 | 酶 & 辅酶 |
| 安全信息 |
|
个人防护装备 |
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|
WGK德国 |
3 |
|
RTECS |
RQ8455000 |
|