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中文名称英文名称CAS 编号规格目录价所属品牌订货号
若丹明 123Rhodamine 12362669-70-95MG¥284.00SIGMAR8004
若丹明 123Rhodamine 12362669-70-925MG¥1,088.00SIGMAR8004
若丹明 123Rhodamine 12362669-70-9100MG¥3,292.00SIGMAR8004
若丹明 123Rhodamine 12362669-70-91G¥25,670.00SIGMAR8004
品牌SIGMA
产品名称 若丹明 123 : Rhodamine 123 ——【产品编号:SIGMA-R8004】
CAS编号62669-70-9
别名罗丹明 123,2-(6-Amino-3-imino-3H-xanthen-9-yl)benzoic acid methyl ester
级别生物染色剂级
纯度&分析mitochondrial specific fluorescent dye
Tips一种常用的生物染色剂,可用于科研、辅料、规模化生产等。
分子式 C21H17ClN2O3
分子量380.82
储存条件常温避光保存。
性质
Appearance (Color) Red to Brown
Appearance (Form) Powder
Infrared spectrum Conforms to Structure
Carbon (dry basis) 62,2 - 70,2 %
Nitrogen (dry basis) 6,9 - 7,8 %
Water (by Karl Fischer) ≤10,0 %
Solubility (Turbidity) Clear to Slightly Hazy
  1mg/ml in Ethanol
Solubility (Color) Conforms to Requirements
  Yellow-Orange
原产地美国
描述

Application

Useful as a laser dye and to have selective cell growth effects. Mitochondrial specific fluorescent dye and substrate for P-glycoprotein.

Biochem/physiol Actions

Fluorescent dye most commonly used in flow cytometry as functional reporter for Pgp. Functional assays for MDR proteins are better prognostic indicators in cancer therapy than levels of MDR protein expression. Rh 123 can be used in multiparameter analyses without fluorescence interference in combination with common protein labeling dyes such as PE-Cy5 and AMCA (7-amino-4-methylcoumarin-3-acetic acid). Recent reports indicate Rh 123 may also be a substrate of MRP1.

供货状态True
参考文献

Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro. Bernal, S.D., et al. Science 218, 1117, (1982)

Clinical significance of P-glycoprotein expression and function for response to induction chemotherapy, relapse rate and overall survival in acute leukemia. Wuchter, C., et al. Haematologica 85, 711-721, (2000)

DiOC2(3) is not a substrate for multidrug resistance protein (MRP)-mediated drug efflux. Minderman, H., et al. Cytometry 25, 14-20, (1996)

Merck 14,10356

类型染色剂
安全信息
个人防护装备  Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK德国  3
RTECS  ZE0883000