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中文名称英文名称CAS 编号规格目录价所属品牌订货号
乙酰辅酶 A,钠盐Acetyl coenzyme A sodium salt102029-73-21MG¥486.00SIGMAA2056
乙酰辅酶 A,钠盐Acetyl coenzyme A sodium salt102029-73-210MG¥1,919.00SIGMAA2056
乙酰辅酶 A,钠盐Acetyl coenzyme A sodium salt102029-73-2100MG¥10,559.00SIGMAA2056
品牌SIGMA
产品名称 乙酰辅酶 A,钠盐 : Acetyl coenzyme A sodium salt ——【产品编号:SIGMA-A2056】
CAS编号102029-73-2
别名乙酰基辅酶A,Acetyl CoA Acetyl-S- CoA
级别科学级
纯度&分析≥93% (HPLC), powder
Tips乙酰辅酶A在酶乙酰转移反应中是乙酰基团必需的载体和辅助因子。
分子式 C23H38N7O17P3S
分子量809.57
储存条件-20 °C 低温冷冻保存。
性质
Related Categories Biochemicals and Reagents, Coenzyme A and Other Acyl Transfer Reagents, Cofactors, Core Bioreagents, Enzymes, Inhibitors, and Substrates, Esters, Fatty Acid Metabolism, Fatty Acids, Fatty acyl CoAs, General Reagents, Life Science Reagents for Transfection, Lipid, Lipid Library, Lipids, Metabolic Libraries, Metabolic Pathways, Metabolites and Cofactors on the Metabolic Pathways Chart, Metabolomics, Nucleosides and Nucleotides, Research Essentials, Saturated fatty acids and derivatives, TCA, Terpenoid Metabolism.
Quality Level PREMIUM
assay ≥93% (HPLC)
form powder
solubility H2O: soluble100 mg/mL
storage temp. −20°C
原产地美国
描述

Application

An essential cofactor in enzymatic acetyl transfer reactions.

Acetyl-CoA is an essential cofactor and carrier of acyl groups in enzymatic acetyl transfer reactions. It is formed either by the oxidative decarboxylation of pyruvate in mitochondria, by the oxidation of long-chain fatty acids, or by the oxidative degradation of certain amino acids. Acetyl-CoA is the starting compound for the citric acid cycle (Kreb′s cycle). It is also a key precursor in lipid biosynthesis, and the source of all fatty acid carbons. Acetyl-CoA positively regulates the activity pyruvate carboxylase. It is a precursor of the neurotransmitter acetylcholine. Histone acetylases (HAT) use Acetyl-CoA as the donor for the acetyl group use in the post-translational acetylation reactions of histone and non-histone proteins.

Preparation Note

Prepared enzymatically.

Biochem/physiol Actions

Acetyl-CoA is an essential cofactor and carrier of acyl groups in enzymatic acetyl transfer reactions. It is formed either by the oxidative decarboxylation of pyruvate in mitochondria, by the oxidation of long-chain fatty acids, or by the oxidative degradation of certain amino acids. Acetyl-CoA is the starting compound for the citric acid cycle (Kreb′s cycle). It is also a key precursor in lipid biosynthesis, and the source of all fatty acid carbons. Acetyl-CoA positively regulates the activity pyruvate carboxylase. It is a precursor of the neurotransmitter acetylcholine. Histone acetylases (HAT) use Acetyl-CoA as the donor for the acetyl group use in the post-translational acetylation reactions of histone and non-histone proteins.

供货状态True
参考文献

Luebben WR, Sharma N, et al., Nucleosome eviction and activated transcription require p300 acetylation of histone H3 lysine 14. Proc. Natl. Acad. Sci. U. S. A. 107, 19254-19259, (2010)

Aka JA, Kim GW, Yang XJ., K-acetylation and its enzymes: overview and new developments. Handb. Exp. Pharmacol. 206, 1-12, (2011)

Hynes MJ, Murray SL, et al., Role of carnitine acetyltransferases in acetyl coenzyme A metabolism in Aspergillus nidulans. Eukaryot. Cell 10, 547-555, (2011)

Singh P, Ponnan P, Priya N, et al., Protein acyltransferase function of purified calreticulin: the exclusive role of P-domain in mediating protein acylation utilizing acyloxycoumarins and acetyl CoA as the acyl group donors. Protein Pept. Lett. 18, 507-517, (2011)

Szutowicz, A., Key role of acetyl-CoA in cytoplasm of nerve terminals in disturbances of acetylcholine metabolism in brain. Folia Neuropathol. 35, 241, (1997)

Decker, K., Bergmeyer, H.U., ed. Meth. Enzym. Anal. 7, 186-200, (1985)

Beutler, H., Supp, M., Bergmeyer, H.U., ed. Meth. Enzym. Anal. 2, 329-330, (1984)

Garland P.B., Bergmeyer, H.U., ed. Meth. Enzym. Anal. 7, 206-211, (1985)

Dutnall, R.N., et al., Structure of the Histone Acetyltransferase Hat1 Cell 94, 427-438, (1998)

Li R, Gu J, Chen P, et al., Purification and characterization of the acetyl-CoA synthetase from Mycobacterium tuberculosis. Acta Biochim. Biophys. Sin. (Shanghai) 43(11), 891-9, (2011)

类型酶 & 辅酶
安全信息
个人防护装备 Eyeshields, Faceshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
风险声明 23/24/25-36/38-39/23/24/25-66-67
安全声明 24-36/37-45
WGK德国 3