中文名称英文名称CAS 编号规格所属品牌订货号
全反式维A酸(维甲酸)Retinoic acid302-79-4100MGSIGMAR2625
全反式维A酸(维甲酸)Retinoic acid302-79-4500MGSIGMAR2625
全反式维A酸(维甲酸)Retinoic acid302-79-41GSIGMAR2625
全反式维A酸(维甲酸)Retinoic acid302-79-45GSIGMAR2625
品牌SIGMA
产品名称 全反式维A酸(维甲酸) : Retinoic acid ——【产品编号:SIGMA-R2625】
CAS编号302-79-4
别名视黄酸,ATRA Tretinoin Vitamin A acid
级别科学级
纯度&分析≥98% (HPLC), powder
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分子式C20H28O2
分子量300.44
储存条件-20 °C 低温冷冻保存。
性质

用途及描述:科研试剂,广泛应用于分子生物学,药理学等科研方面。本品为细胞诱导分化药。维A酸是维生素A的代谢中间体,主要影响骨的生长与上皮代谢。通过调节表皮细胞的有丝分裂和表皮细胞的更新,促进正常角化,影响上皮代谢,对上皮角细胞的生长和角质层的脱落有明显的促进作用,可促使已有的粉刺去除,同时又抑制新的粉刺;可阻止角质栓的堵塞,对角蛋白的合成有抑制作用。

InChI Key    SHGAZHPCJJPHSC-YCNIQYBTSA-N 
assay    ≥98% (HPLC) 
form    powder 
color    yellow 
mp    180-181 °C(lit.) 
storage temp.    −20°C 

原产地美国
描述

Application

• Retinoic acid (RA) has been used for the differentiation of embryonic stem cells into motor neurons.[1]
• It has been used for the differentiation of Xenopus ectoderm into pancreas.[2]
• It has also been used to study epigenetic regulation by RARα (retinoic acid receptor α).[3]
• It has been used to study RA signaling of prospermatogonia transition into spermatogonia.[4]


Biochem/physiol Actions

all−trans−Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

法律信息

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

供货状态True
参考文献N/A
类型维生素
安全信息

符号   GHS07  GHS07 
信号词   Warning 
危害声明   H302 
警示性声明   P301 + P312 + P330 
个人防护装备   dust mask type N95 (US), Eyeshields, Gloves 
危害码 (欧洲)   Xn 
风险声明 (欧洲)   22 
安全声明 (欧洲)   61 
RIDADR   UN 3077 9 / PGIII 
WGK德国   2 
RTECS   VH6475000