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中文名称英文名称CAS 编号规格目录价所属品牌订货号
制霉菌素Nystatin1400-61-9100MG¥210.00SIGMAN3503
制霉菌素Nystatin1400-61-91G¥1,350.00SIGMAN3503
制霉菌素Nystatin1400-61-95G¥3,900.00SIGMAN3503
品牌SIGMA
产品名称 制霉菌素 : Nystatin ——【产品编号:SIGMA-N3503】
CAS编号1400-61-9
别名米可定,制霉素,制真菌素,Fungicidin,Mycostatin
级别科学级
纯度&分析≥4,400 USP units/mg
Tips靠结合到膜的甾醇增加敏感性真菌细胞膜的渗透性。
分子式N/A
分子量N/A
储存条件-20 °C 低温冷冻保存。
性质

Appearance (Color) : Yellow
Appearance (Form) : Powder
Solubility (Color) : Light Yellow-Green to Dark Yellow
Solubility (Turbidity) : Clear to Hazy,2 mg/mL, MeOH with a few insolubles
Water (by LOD) : <_ 6.0 %
Cell Culture Test : Pass
Potency (Dried Basis) : >_ 4400 USP unit/mg
pH,3% solution : 6.0 - 8.0
Plant Cell Culture Test : Pass

原产地美国
描述

Biochem/physiol Actions

Mode of Action: Increases the permeability of the cell membrane of sensitive fungi by binding to sterols.
Antimicrobial spectrum: Yeasts and molds.

Nystatin binds to ergosterol in fungal cell membranes which causes the formation of pores in the membrane. Potassium and other cellular constituents leak from the pores causing cell death. Antimicrobial spectrum: Yeasts and molds.

Application

Product N3503 is ≥4,400 USP units/mg. Nystatin is a polyene, antifungal antibiotic with potent proinflammatory properties. It has many applications such as preventing cell culture contamination and inducing interleukin (IL)-, IL-8, and tumor necrosis factor α s secretion in TLR2-expressing THP1 cells 1. It is used as a fungal membrane (ergosterol binding) pore forming agent and to create nystatin/ergosterol based ion channels in lipid bilayers.

供货状态True
参考文献

1. Raymund R. Razonable, Martin Henault, et al., Nystatin Induces Secretion of Interleukin (IL)-1β, IL-8, and Tumor Necrosis Factor α by a Toll-LikeReceptor-Dependent Mechanism. Antimicrob. Agents Chemother. 49, 3546-3549, (2005)

Brezis, M. Science 224, 66, (1984)

Merck 14,6736

类型抗生素
安全信息
个人防护装备 Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
安全声明 22-24/25
WGK德国 2
RTECS RF5950000