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中文名称英文名称CAS 编号规格目录价所属品牌订货号
细胞松驰素 BCytochalasin B from Drechslera dematioidea14930-96-21MG¥875.72SIGMAC6762
细胞松驰素 BCytochalasin B from Drechslera dematioidea14930-96-25MG¥3,760.26SIGMAC6762
细胞松驰素 BCytochalasin B from Drechslera dematioidea14930-96-225MG¥14,586.76SIGMAC6762
细胞松驰素 BCytochalasin B from Drechslera dematioidea14930-96-210X5MG¥35,000.00SIGMAC6762
品牌SIGMA
产品名称 细胞松驰素 B : Cytochalasin B from Drechslera dematioidea ——【产品编号:SIGMA-C6762】
CAS编号14930-96-2
别名松胞菌素B,松胞素B,Phomin
级别科学级
纯度&分析≥98% (HPLC), powder
Tips一种常用的研究级抗生素类制品,适用于科学研究、辅料、规模化生产等。
分子式 C29H37NO5
分子量479.61
储存条件-20 °C 低温冷冻保存。
性质
Quality Level PREMIUM
assay ≥98% (HPLC)
form powder
color white
solubility DMSO: soluble10 mg/mL
storage temp. −20°C
原产地美国
描述

Biochem/physiol Actions

One of a group of fungal metabolites that interfere with a wide variety of cellular movements. Useful tool for characterizing some of the polymerization properties of actin,1 and in studies on cytokinesis.2 Probe for the two hexose-transport systems in rat L6 myoblasts.3

Cell permeable fungal toxin that disrupts contractile microfilaments by inhibiting actin polymerization. This, in turn, induces DNA fragmentation, inhibits cell division, and disrupts many cell processes. Inhibits glucose transport.

供货状态True
参考文献

1. E.D.Korn Physiol. Rev. 62, 672, (1982)

2. S. Eperon J. Protozool. 33, 43, (1986)

3. S.R.Chen Biochem. J. 251, 3, (1988)

Theodoropoulos, P.A., et al., Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end capping. Biochem. Pharmacol. 47, 1875-1881, (1994)

Kilber, M.A., et al., Cytochalasin B induces cellular DNA fragmentation. FASEB J. 4, 3021-3027, (1990)

Cimini, D., et al., Simultaneous inhibition of contractile ring and central spindle formation in mammalian cells treated with cytochalasin B. Chromosoma 107, 479-485, (1998)

Soreng, K.M., et al., A role for microfilaments but not microtubules in processing soluble antigens. Cell. Immunol. 166, 25-34, (1995)

Toyohara, A., and Inaba, K., Transport of phagosomes in mouse peritoneal macrophages. J. Cell Sci. 94 ( Pt 1), 143-153, (1989)

Forscher, P., and Smith, S.J., Actions of cytochalasins on the organization of actin filaments and microtubules in a neuronal growth cone. J. Cell Biol. 107, 1505-1516, (1988)

Chien, C.B., et al., Navigational errors made by growth cones without filopodia in the embryonic Xenopus brain. Neuron 11, 237-251, (1993)

Walmsley, A.R., et al., Sugar transporters from bacteria, parasites and mammals: structure-activity relationships. Trends Biochem. Sci. 23, 476-481, (1998)

Pedro Goncalves, et al., Lack of a significant effect of cannabinoids upon the uptake of 2-deoxy-D-glucose by Caco-2 cells. Pharmacology 82, 30-37, (2008)

Bylund, J., et al., Cytochalasin B triggers a novel pertussis toxin sensitive pathway in TNF-alpha primed neutrophils. BMC Cell Biol. 5, 21, (2004)

Diaz-Ricart M., et al., Inhibition of cytoskeletal assembly by cytochalasin B prevents signaling through tyrosine phosphorylation and secretion triggered by collagen but not by thrombin. Am. J. Pathol. 160, 329-337, (2002)

Thompson, B.Y., et al., Oxygen Metabolism Of The HL-60 Cell Line: Comparison Of The Effects Of Monocytoid And Neutrophilic Differentiation. J. Neurochem. 43, 140-7, (1988)

Ila, H.B., et al., Genotoxic potential of cyfluthrin. Mutat. Res. 656, 49-54, (2008)

Sun, X., et al., Adeno-associated virus-targeted disruption of the CFTR gene in cloned ferrets. J. Comp. Neurol. 118, 1578-83, (2008)

Rencüzoğullari, E., et al., The effects of food protector biphenyl on sister chromatid exchange, chromosome aberrations, and micronucleus in human lymphocytes. Drug Chem. Toxicol. 31, 263-74, (2008)

Brzozowska, K., et al., Effect Of Temperature During Irradiation On The Level Of Micronuclei In Human Peripheral Blood Lymphocytes Exposed To X-rays And Neutrons. Int. J. Radiat. Biol. 85, 891-9, (2009)

Buyukleyla, M., and Rencuzogullari, E., The effects of thymol on sister chromatid exchange, chromosome aberration and micronucleus in human lymphocytes. Ecotox. Environ. Safety 72, 943-7, (2009)

Lavrentyev, E.N., and Malik, K.U., High glucose-induced Nox1-derived superoxides downregulate PKC-betaII, which subsequently decreases ACE2 expression and ANG(1-7) formation in rat VSMCs. Am. J. Physiol. Heart Circ. Physiol. 296, H106-18, (2009)

Fan, Y., et al., Developmental potential of human oocytes reconstructed by transferring somatic cell nuclei into polyspermic zygote cytoplasm. Biochem. Biophys. Res. Commun. 382, 119-23, (2009)

Paula, F.S., et al., Modulation of human neutrophil oxidative metabolism and degranulation by extract of Tamarindus indica L. fruit pulp. Food Chem. Toxicol. 47, 163-70, (2009)

Rencüzoğullari, E., et al., Effects of natamycin on sister chromatid exchanges, chromosome aberrations and micronucleus in human lymphocytes. Drug Chem. Toxicol. 32, 47-52, (2009)

Sharma, N.R., et al., Reciprocal Regulation Of AKT And MAP Kinase Dictates Virus-host Cell Fusion. J. Virol. 84, 4366-82, (2010)

Johannes, C., et al., The Yield Of Radiation-induced Micronuclei In Early And Late-arising Binucleated Cells Depends On Radiation Quality. Mutat. Res. 701, 80-85, (2010)

Chen, X., et al., Similar DNA Methylation And Histone H3 Lysine 9 Dimethylation Patterns In Tripronuclear And Corrected Bipronuclear Human Zygotes. J. Reprod. Dev. 56, 324-9, (2010)

Tang, D., et al., Reconstitution Of The Cell Cycle-regulated Golgi Disassembly And Reassembly In A Cell-free System. Nat. Protoc. 5, 758-72, (2010)

Merck 14,2790

类型抗生素
安全信息
符号 GHS06GHS08
信号词 Danger
危险声明 H300-H310-H330-H361
警示性声明 P260-P264-P280-P284-P301 + P310-P302 + P350
个人防护装备 Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
危害码 T+
风险声明 26/27/28-63
安全声明 28-36/37-45
RIDADR UN 1544 6.1/PG 2
WGK德国 3
RTECS RO0205000